Thokhir Shaik

Developed a Random Forest QSAR pipeline for SARS-CoV-2 bioactivity using RDKit/MACCS descriptors and ChEMBL-curated datasets (pIC50 prediction, R²≈0.47). Conducted multi-omics biomarker discovery from NCBI GEO and TCGA/GEO transcriptomic workflows, identifying candidate biomarkers for salt-stress response and cholangiocarcinoma while building reproducible Python pipelines for validation.

Led the Indo-EU Horizon 2020 SPRING project with 14 international partners, delivering all objectives ahead of schedule despite COVID-19. Standardized EU-compliant water testing protocols across 72+ sampling points, used multivariate stats (PCA/ANOVA/RDA) and Python ML (SVM/ANN/XGBoost) for water-quality forecasting, and improved lab workflow efficiency by 22% while achieving >98% analytical compl

Screened >500 microbial cultures to identify nitrilase-producing strains and developed a patented acrylonitrile-to-acrylic acid bioconversion process with 70–80% yield, validated by NMR/LC-MS and HPLC method development (LOQ/LOD established). Conducted tubulin-targeting and anticancer cell-based mechanistic validation, and developed thermodynamically stable oil-in-water microemulsion systems to im

Developed and validated six rapid bacterial pathogen detection kits for drinking water, creating complete manufacturing SOPs for municipal-scale deployment and securing city-wide orders for municipal monitoring. Built and validated a 100 L Moving Bed Biofilm Reactor (MBBR) prototype, engineered an ozone-based vegetable washer for targeted pesticide/contaminant degradation, and delivered multiple f

PhD in Biotechnology at CSIR-Indian Institute of Chemical Technology (2012–2019) focused on cancer biology, drug discovery, and microemulsion-based drug delivery systems.