Dr amala kompella
@dramalakompella
Senior pharmaceutical scientist specializing in preclinical drug discovery and process development.
IndiaWhat I'm looking for
I am a senior pharmaceutical scientist with ~27 years' experience in bulk drug process development and 20 years in preclinical drug discovery, having led discovery and process teams and authored multiple patents.
I designed potent imatinib analogs (IC50 < 10 nM), contributed to a molecule that completed Phase I and achieved orphan drug status, and am the main inventor on 36 patents; I established preclinical discovery capabilities and led cross-functional teams to advance PI3K and immuno-oncology programs.
I have deep expertise in technology transfer, commercialization, IPR and regulatory matters, molecular modeling (LigandFit, Glide), and large-scale process execution, with a track record of producing plant-scale batches and publishing peer-reviewed research.
Experience
Work history, roles, and key accomplishments
Senior General Manager (R&D)
Natco Pharma Limited
Nov 2019 - Jun 2025 (5 years 7 months)
Established and led preclinical discovery department, advanced PI3K and immuno-oncology programs, and managed process development and scale-up of multiple oncology APIs including imatinib mesylate with production at 400 kg plant scale.
General Manager (R&D)
Natco Pharma Limited
Dec 2000 - Aug 2018 (17 years 8 months)
Led R&D efforts across discovery and process development, contributed to imatinib mesylate process innovation (alpha-2 crystal form) and secured patents and industry awards for cost-effective industrial processes.
Research Associate
Vera Laboratories Ltd
Nov 1998 - Nov 2000 (2 years)
Executed process development for active pharmaceutical ingredients, focusing on scalable, industrially viable synthetic routes and impurity control.
R&D Chemist
Indian Chemphar Limited
May 1997 - Aug 1998 (1 year 3 months)
Developed and stabilized benzenoid aromatic processes, optimizing yields and product stability for manufacturing applications.
R&D Chemist
Synat Organics Limited
Jan 1995 - Oct 1996 (1 year 9 months)
Conducted process development of benzenoid aromatics, improving synthetic routes and transferability to pilot-scale production.
Lecturer (Chemistry)
Satavahana Mahila College
Sep 1992 - Dec 1994 (2 years 3 months)
Taught undergraduate chemistry courses and supervised practical laboratory sessions for chemistry students.
Education
Degrees, certifications, and relevant coursework
Jawaharlal Nehru Technological University, Hyderabad
Doctor of Philosophy, Chemistry
2007 - 2014
Ph.D. with thesis titled 'Therapeutically useful phenylamino pyrimidines' completed between 2007 and 2014.
BDPS (Diploma issuer)
Diploma, Computer Technology
Grade: I division
Diploma in Advanced Computer Technology, awarded First Division in 2000.
Nagarjuna University
Master of Science, Chemistry
Grade: 73%
Completed M.Sc. in Chemistry with 73% and University 3rd rank in 1992.
Availability
Location
IndiaAuthorized to work in
Job categories
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