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Dr amala kompellaDK
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Dr amala kompella

@dramalakompella

Senior pharmaceutical scientist specializing in preclinical drug discovery and process development.

India
Message

What I'm looking for

I seek senior R&D roles where I can lead preclinical discovery and process development teams, drive translation to clinic, handle IPR/tech transfer, and mentor cross-functional scientists in a collaborative, innovation-focused environment.

I am a senior pharmaceutical scientist with ~27 years' experience in bulk drug process development and 20 years in preclinical drug discovery, having led discovery and process teams and authored multiple patents.

I designed potent imatinib analogs (IC50 < 10 nM), contributed to a molecule that completed Phase I and achieved orphan drug status, and am the main inventor on 36 patents; I established preclinical discovery capabilities and led cross-functional teams to advance PI3K and immuno-oncology programs.

I have deep expertise in technology transfer, commercialization, IPR and regulatory matters, molecular modeling (LigandFit, Glide), and large-scale process execution, with a track record of producing plant-scale batches and publishing peer-reviewed research.

Experience

Work history, roles, and key accomplishments

Natco Pharma Limited logoNL

Senior General Manager (R&D)

Natco Pharma Limited

Nov 2019 - Jun 2025 (5 years 7 months)

Established and led preclinical discovery department, advanced PI3K and immuno-oncology programs, and managed process development and scale-up of multiple oncology APIs including imatinib mesylate with production at 400 kg plant scale.

Natco Pharma Limited logoNL

General Manager (R&D)

Natco Pharma Limited

Dec 2000 - Aug 2018 (17 years 8 months)

Led R&D efforts across discovery and process development, contributed to imatinib mesylate process innovation (alpha-2 crystal form) and secured patents and industry awards for cost-effective industrial processes.

VL

Research Associate

Vera Laboratories Ltd

Nov 1998 - Nov 2000 (2 years)

Executed process development for active pharmaceutical ingredients, focusing on scalable, industrially viable synthetic routes and impurity control.

IL

R&D Chemist

Indian Chemphar Limited

May 1997 - Aug 1998 (1 year 3 months)

Developed and stabilized benzenoid aromatic processes, optimizing yields and product stability for manufacturing applications.

SC

Lecturer (Chemistry)

Satavahana Mahila College

Sep 1992 - Dec 1994 (2 years 3 months)

Taught undergraduate chemistry courses and supervised practical laboratory sessions for chemistry students.

Education

Degrees, certifications, and relevant coursework

Jawaharlal Nehru Technological University, Hyderabad logoJH

Jawaharlal Nehru Technological University, Hyderabad

Doctor of Philosophy, Chemistry

2007 - 2014

Ph.D. with thesis titled 'Therapeutically useful phenylamino pyrimidines' completed between 2007 and 2014.

BI

BDPS (Diploma issuer)

Diploma, Computer Technology

Grade: I division

Diploma in Advanced Computer Technology, awarded First Division in 2000.

NU

Nagarjuna University

Master of Science, Chemistry

Grade: 73%

Completed M.Sc. in Chemistry with 73% and University 3rd rank in 1992.

Tech stack

Software and tools used professionally

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Dr amala kompella - Senior General Manager (R&D) - Natco Pharma Limited | Himalayas