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Olga Pyalling

@olgapyalling

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I build computational and synthetic biology tools for preclinical product validation.

United States

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What I'm looking for

I'm seeking opportunities to advance synthetic and systems biology applications through R&D, computational modeling, and preclinical product validation.

I've supported Ocular Therapeutix's Phase III AXPAXLI formulation documentation while characterizing biodegradable hydrogel implants and analyzing API release data.

At Northeastern and Hollister, I developed a patient-derived 3D peristomal tissue model and built an ANSYS finite element simulation for virtual mechanical testing before fabrication.

I've engineered a dual-inducible eYFP/mScarlet recombinant plasmid system, achieving inducer-specific fluorescence and validating integration through Sanger sequencing and plate-reader assays.

I also built a Python program to assess E. coli cell-line and plasmid compatibility, bringing together computational modeling, genetic engineering, and experimental validation.

Experience

Work history, roles, and key accomplishments

Capstone: In-Silico Finite Element Model of Peristomal Tissue Mechanics

Northeastern University College of Engineering and Hollister

Jul 2024 - Dec 2024 (5 months)

Developed patient-derived 3D computational model of peristomal tissue from abdominal CT scans using SolidWorks, enabling virtual mechanical testing. Built finite element simulation in ANSYS implementing an Ogden hyper elastic material model with viscoelastic add-on.

Solidworks Ansys FEA Matlab R ANOVA Computational Modeling 3D Modeling

R&D Engineer Co-op

Ocular Therapeutix, Inc.

Jul 2023 - Dec 2023 (5 months)

Conducted research for official Phase III formulation documentation of biodegradable hydrogel delivery technology, AXPAXLI, following GLP standards. Executed experiments characterizing AXPAXLI implants and analyzed API release data.

Excel Keyence SEM HPLC IVR API Assay UV Vis GLP GDP literature review Data Analysis

Education

Degrees, certifications, and relevant coursework

Northeastern University

Graduate Certificate, AI Applications for Business

Grade: 3.9

Graduate Certificate in AI Applications for Business with a GPA of 3.9, expected completion in May 2026.

Northeastern University

Bachelor of Science, Bioengineering

Grade: 3.6

Activities and societies: Dean's List '20 – '24, Chamillard Family Engineering Scholarship, iGEM Selected Member, Equestrian Team/IHSA (Regional Qualifier)

B.S. in Bioengineering with a concentration in Synthetic, Systems, and Computational Biology, graduated cum laude with a GPA of 3.6.