I am looking for a role that fosters innovation and collaboration in biotechnology, with opportunities for research and professional growth. I am a computational biology enthusiast and am seeking opportunity to work on projects remotely.
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@dhruvripudemansinghb
Final year undergraduate passionate about biotechnology and research.
I am looking for a role that fosters innovation and collaboration in biotechnology, with opportunities for research and professional growth. I am a computational biology enthusiast and am seeking opportunity to work on projects remotely.
I am a final year undergraduate student at the Indian Institute of Technology Kharagpur, pursuing a dual degree in Biotechnology and Biochemical Engineering. With a GPA of 9.23/10.00, I have developed a strong foundation in systems and synthetic biology, computational biology, and cell metabolism. My research experience includes working on various projects, such as identifying dysregulated metabolic pathways in liver cancer and investigating mitochondrial adaptations under thermal stress. I thrive in collaborative environments and am driven by the desire to contribute to innovative solutions in biotechnology.
Throughout my academic journey, I have been recognized for my achievements, including being awarded the Ministry of Human Resource Development Graduate Fellowship and the Best Poster Presentation Award at the Horizons of Structural and Computational Biology Conference. I have also gained valuable experience as a teaching assistant, where I demonstrated experimental techniques and supported students in laboratory settings. I am eager to apply my skills and knowledge in a challenging role that allows me to further explore the intersections of biology and technology.
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Work history, roles, and key accomplishments
Indian Institute of Technology Kharagpur
Aug 2024 - Present (1 year 3 months)
Integrated normalized liver cancer transcriptomics data with Human-GEM model using COBRA Toolbox in MATLAB. Executed Differential Flux Analysis to decipher altered metabolic pathways and constructed a Drug-Gene Interaction Network for potential therapeutics.
Institute for Stem Cell Science and Regenerative Medicine
Jan 2024 - Present (1 year 10 months)
Investigated stress-induced mitochondrial metabolic adaptations using a yeast mitochondrial genome-scale model. Mapped differential gene expression of yeast cells to mitochondrial metabolic fluxes in MATLAB and implemented integration algorithms to refine flux distributions.
Indian Institute of Technology Kharagpur
Jan 2025 - Apr 2025 (3 months)
Demonstrated and supervised experimental techniques including protein quantification and enzyme kinetics assays. Provided hands-on training in pipetting, reagent preparation, lab safety, experimental design, and data interpretation.
Indian Institute of Technology Kharagpur
Aug 2024 - Nov 2024 (3 months)
Assisted in preparing lab protocols, demonstrating experiments, and teaching basic working principles of biosensors. Supported students in using biosensor devices, including sensor calibration and data interpretation during lab sessions.
Institute for Stem Cell Science and Regenerative Medicine
May 2024 - Aug 2024 (3 months)
Analyzed the impact of mitochondrial respiration on the fluidity of the inner membrane of isolated mitochondria. Isolated GFP-tagged mitochondria from S. cerevisiae and assessed fluidity using Fluorescence Lifetime Imaging Microscopy.
Indian Institute of Technology Kharagpur
Jun 2022 - Aug 2024 (2 years 2 months)
Investigated metabolic alterations across healthy and NAFLD-affected liver tissues using differential flux analysis. Pre-processed and TPM-normalized transcriptomics data with R, reconstructed context-specific models in MATLAB, and performed analysis using CobraPy in Python.
National University of Singapore
Jun 2023 - Aug 2023 (2 months)
Engineered E. coli for DNA transfer to mammalian mitochondria using antigen-nanobody binding. Executed nanobody expression via plasmid cloning and achieved antigen expression on HEK293 cells, verifying transfer via PCR-based detection.
Indian Institute of Technology Kharagpur
Oct 2022 - Apr 2023 (6 months)
Determined differentially expressed genes in metabolic disorders and their associations with circadian rhythm. Performed differential gene expression analysis on bulk cell RNA-Seq datasets using Limma in R and visualized data with Volcano Plot and Heatmap.
Zummit Info Labs
May 2022 - Jul 2022 (2 months)
Developed a user-friendly toolbox for predictive analysis of mutation consequences of amino acid sequences. Designed a 'Mutation Tool' interface using HTML, CSS, and JavaScript, integrating mutation capabilities with an embedded library.
Degrees, certifications, and relevant coursework
Bachelors of Technology (Honours) and Master of Technology , Biotechnology and Biochemical Engineering
2020 - 2025
Grade: 9.23
Activities and societies: National Service Scheme (NSS), National Cultural Appreciation - Dance (NCA), Spectra (Fine Arts Club)
Final-year undergraduate at IIT Kharagpur, majoring in Biotechnology and Biochemical Engineering, led research in Systems and Synthetic Biology, Molecular Biology, and Computational Biology.
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