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Denver Ncube

@denverncube

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Bioinformatician/computational with 9 years experience in NGS data analysis.

United States

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What I'm looking for

I am looking for a position where I can be involved in using actionable intelligence from precision medicine to enhance clinical outcomes or inform therapeutic development.

I am a multidisciplinary expert in the biomedical sciences with professional experience in various basic and clinical disciplines, ranging from clinical anatomy, developmental biology, neuroscience, cell molecular biology and computational biology. I have successfully led the development of high quality bioinformatics pipelines for scientific and clinical use as well as optimizing analytical pipelines in a regulated environment (CAP & CLIA). I am interested in bioinformatics/computational biology roles in a clinical translational setting.

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Experience

Work history, roles, and key accomplishments

Clinical Translational Scientist

Alimentiv

Jun 2024 - Apr 2025 (10 months)

• Provided expert input on design and conduct of clinical studies incorporating Precision Medicine endpoints and or “omics and non-omics” techniques including but not limited to transcriptomics (bulk, single cell and spatial-10X Visium), metabolomics, proteomics, microbiome, digital image analysis and or clinical pharmacology.

Precision Health Consultant

Theriome

Feb 2024 - Jun 2024 (4 months)

I was responsible for carrying out client consultations in personalized metabolomics data analysis.
I also engaged with physicians and other Key Opinion Leaders to advance the utility of metabolomics in standard therapeutic planning.

Communication Skills Problem Solving Patient Engagement

Computational Biologist I

Flagship Biosciences

Mar 2023 - Jan 2024 (10 months)

Joined as a computational biologist and led the development of custom pipelines for next generation sequencing data analysis which are CLIA/CAP guideline compliant. I also collaborated cross-functionally to assist the migration of NGS data processing pipelines onto Amazon S3.

Python Project Management R Shiny

Data Scientist

Freelance

Aug 2021 - Feb 2023 (1 year 6 months)

Designed high throughput Machine Learning transcriptional profiling protocols for neurons to enable site-specific drug development. Led the project management team for implementation of Natural Language Processing (NLP) for Dialect Dialogue
African language preservation project. Optimized RNAseq data analysis pipelines adhering to best practices using common workflow languages such as SnakeMake

Python Project Management R

Research Scientist

University of Oregon

Jun 2021 - Aug 2021 (2 months)

Analyzed and curated bulk and single cell RNAseq data from zebrafish multi-transmitter neurons using R-Studio and Python bio-informatics packages (BioConductor, STAR, DESEq2, TopGO,Seurat, GATK, picard, samtools
etc) for 3 publications. Utilized various data visualization packages in R (R-Shiny, Plotly, ggplot) and Python(Seaborn) to enhance extraction of insights from bulk and scRNAseq.

Python R Project Management

Graduate Research Scientist

University of Oregon

Sep 2016 - Jun 2021 (4 years 9 months)

Utilized bioinformatic platforms (Benchling, Geneious,Ensembl[BLAT,BLAST etc], Genome Browser, CCTOP, CRISPRScan) in optimizing the design of single guide RNA.
Optimized multi-plexed CRISPR/Cas9 gene editing to knockout genes in reverse genetic screens in zebrafish. Designed data analysis pipelines for single cell and bulk RNA sequencing data including data visualization tools.

Python Project Management R