ANG (ANDY) TU

Built modular Snakemake pipelines to streamline single-cell RNA-seq analysis, expanded internal single-cell reference atlases 5× to improve annotation accuracy, and developed Python modeling tools integrating scVI/scANVI; supervised two computational biologists to align cross-platform projects.

Advised experimental and sequencing design for low-input antibody repertoire workflows and enhanced analytic strategies for immunoglobulin reconstruction and quality assessment to improve data quality and interpretability.

Led multiplex immunofluorescence (Akoya mIF) analysis combining image segmentation and ML (CNNs, XGBoost), partnered with wet-lab teams on multi-modal profiling of tumor fragments and humanized mouse models, and improved shared Python/R infrastructure.

Modeled clonal CD8+ T-cell dynamics using multivariate and ML approaches and supported identification of immunotherapeutic target candidates including work on CD83-focused research.

Analyzed TCGA and GTEx to support indication selection for a CD161-targeting therapeutic advancing toward Phase I and developed workflows for tumor immune state analysis and translational biomarker assessment.

Co-designed FastStitch abdominal wall closure device, built SLA 3D-printed prototypes, supported preclinical testing, and helped secure over $250,000 in grants and national innovation awards.

Studied T-cell activation and immune engineering using hydrogel and nanoparticle tools, conducted flow cytometry and HPLC, and developed mechanosensing assays while training junior researchers.

Conducted excipient robustness studies and protein stability assays using CE, HPLC, and UV to support drug product science activities.

Developed ELISA assays for vaccine immunogenicity, performed cloning, RNA extraction, and tissue culture, and trained junior researchers in laboratory techniques.

PhD in Biological/Biosystems Engineering focused on development of high-throughput paired TCR and transcriptome sequencing and single-cell immunology applications.

Grade: 3.96/4.0

Activities and societies: Build-a-Genome; Tau Beta Pi; Biomedical Engineering Society

Bachelor of Science in Biomedical Engineering with a minor in Entrepreneurship & Management; coursework and activities focused on biomedical device design and translational research.