Akwii Grace Racheal

Designed and led in vivo biodistribution studies to assess LNP-mRNA payload performance via molecular and protein-level readouts, developing targeted delivery strategies. Authored and QC'd technical reports aligned with SOPs and regulatory guidelines, applying Snapgene, R/Python to analyze gene expression data. Mentored junior scientists in experimental design, assay execution, and translational d

Advanced three gene therapy programs through cross-functional collaboration with clinical development, biomarker, and platform teams, designing AAV constructs and leading in vitro/in vivo screening. Developed genomic assays to analyze target expression and vector efficacy, contributing to regulatory briefing documents. Supported translational assay development and exploratory biomarker analysis in

Led four translational oncology projects assessing biomarker modulation by targeted therapies using in vivo models, engineering CRISPR-Cas9 knockout models to evaluate tumor and immune cell responses. Conducted exosome analysis, lymphangiogenesis studies, and molecular profiling of tumor microenvironments. Utilized R and Python to analyze and visualize data from flow cytometry, qPCR, and imaging a

Developed and conducted a mechanistic angiogenesis study, specifically focusing on RhoA signaling in lymphatic endothelial cells. This involved designing experiments and executing laboratory procedures to investigate cellular pathways.

Supported national PCR testing efforts and trained medical lab professionals in quality control and reporting practices. Implemented SOPs that significantly reduced assay error rates, enhancing laboratory efficiency and accuracy.

Received comprehensive training in molecular biology workflows, encompassing essential techniques such as RNA/DNA isolation, PCR, sequencing, and gel electrophoresis. Gained practical experience in fundamental laboratory procedures critical for biomedical research.

Activities and societies: Presented data in academic and peer-reviewed forums and mentored graduate trainees in lab practices and experimental design.

Conducted four translational oncology projects, assessing biomarker modulation by targeted therapies using in vivo models. Engineered CRISPR-Cas9 knockout models to evaluate tumor and immune cell responses. Analyzed and visualized data from flow cytometry, qPCR, and imaging assays using R and Python.

Undertook studies in pharmaceutical sciences, focusing on advanced research methodologies and drug development. Gained expertise in various laboratory techniques and data analysis relevant to the field.

Completed a Bachelor of Science in Biomedical Sciences, gaining foundational knowledge in biological and medical sciences. Trained in molecular biology workflows, including RNA/DNA isolation, PCR, sequencing, and gel electrophoresis.