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Sasan Sharee

@sasansharee

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Senior biotechnology scientist specializing in cellular assay development and immuno-oncology screening.

United States

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What I'm looking for

I am seeking a senior research role in biotech or immuno-oncology where I can lead assay development and translational studies, work cross-functionally, and advance therapeutic candidates toward clinical development.

I am a dedicated biotechnology scientist with a Ph.D. in Biochemical Engineering and eight years of experience designing and developing cellular assays for target validation and drug discovery.

I have built and optimized high-throughput screening platforms, engineered cell lines, and developed primary immune-cell and co-culture models that directly supported clinical candidate selection and immuno-oncology programs.

I work well in cross-disciplinary, matrixed environments, excel at assay robustness and scale-up, and bring strong attention to detail, communication, and problem-solving to deliver actionable translational results.

Experience

Work history, roles, and key accomplishments

Senior Scientist

AstraZeneca

Jan 2023 - May 2024 (1 year 4 months)

Developed and optimized monocyte-derived macrophage cellular assays for target validation and small-molecule testing, improving assay robustness for translational immuno-oncology studies.

Cell Based Assays Macrophage Polarization High Content Imaging

Scientist II

NextCure

Mar 2019 - Oct 2022 (3 years 7 months)

Performed validation and mechanism-of-action studies on early-stage targets influencing clinical candidate selection and implemented cell-based and biochemical assays across primary immune cells and cell lines.

Mechanism Of Action Co Culture Systems PHrodo Internalization LEGENDplex

Scientist I

NextCure

Nov 2016 - Mar 2019 (2 years 4 months)

Developed and scaled a high-throughput screening platform for immuno-oncology target discovery, performing large-scale screens using high-content imaging and automated robotic systems.

High Content Imaging Automated Workstations Reporter Assays Primary Monocyte Profiling

Education

Degrees, certifications, and relevant coursework

University of Maryland, Baltimore County

Doctor of Philosophy, Biochemical Engineering

2010 - 2016

Activities and societies: Advisor: Dr. Jennie B. Leach; Dissertation: Investigating the effect of hypoxia and culture dimensionality on human neural stem cells; published related peer-reviewed articles.

Ph.D. in Biochemical Engineering researching effects of hypoxia and culture dimensionality on human neural stem cells, developing 3D hydrogel culture systems and protocols to modulate NSC proliferation and differentiation.