Sr. Scientist, Screening & Compound Profiling

Job Description

The Screening & Compound Profiling group at our Research Laboratories site in Rahway, NJ is looking for a highly motivated, talented and innovative Senior Scientist with a strong background in the development of cellular assays to support phenotypic and target-based small molecule screens, high-content imaging and functional genomic screening, with the goal of identifying novel targets and molecules to drive our drug discovery pipeline across multiple therapeutic areas.

Key Responsibilities:

• Design, plan and execute robust scientific research activities utilizing cell-based assays ‘at-scale’ to accelerate lead discovery in the identification of molecules and targets via small molecule and CRISPR screens

• Develop arrayed CRISPR screening applications in cell lines as well as complex disease-relevant models (primary cells, co-cultures, 3D culture)

• Focus on high throughput (HT)-complex cell models (3D, iPSC, co-culture systems) to enable the development of ‘assays at scale’

• Represent Screening & Compound Profiling on cross-functional project teams influencing strategic direction with data/progress updates & insight

• Contribute to a high-performance culture of inclusion, collaboration, engagement and self-accountability

Education:

• PhD with 0-3 years of experience, Master's Degree with 3-6 years of experience or a Bachelor's Degree with >10 years of experience in assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment

Required Skills & Experience:

• Hands-on experience in the areas of cellular assay development with proficiency in high-content screening and image analysis using primary cultures and cell lines

• Experience in development, execution and analysis of arrayed CRISPR screens

• Extensive development and miniaturization of cell-based assays (384w/ 1536w) using liquid handlers and detectors to support small molecule profiling.

• Demonstrated ability to work under tight timelines and independently execute experimental tasks.

• Guidance of scientific operations, strategy, and communication with a track record of collaboration on multidisciplinary teams in one or more therapeutic area(s).

• Passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues.

• Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.

Preferred Skills and Experience:

• Understanding and application of image and data analysis using both traditional methods as well as AI/ML

• Collaboration to identify, evaluate, and recommend novel and cutting-edge assay development strategies to drive programs in areas including, but not limited to, high throughput-complex cell models, Cell Painting, CRISPR and ML/AI.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

#EligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listedhere.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation: