Sr. Bioinformatics Scientist

About the Role:

At Guardant Health, we are committed to positively and significantly impacting patient health through technology breakthroughs that address long-standing unmet needs in oncology. The Bioinformatics, BioPharma team at Guardant Health is focused on partnerships with leading biotech and pharma companies who are at the forefront of cancer therapeutics and diagnostics. In this role, you will play a key leadership role in bioinformatics and data analysis, supporting the development of emerging technologies. You will collaborate with BioPharma and clinical partners, customize analyses to meet the unique needs of each organization, and address some of the most compelling biological and technical challenges in the field.

You will contribute to novel project initiatives in-house, including the development of novel bioinformatics and analytical methods. As a member of the Bioinformatics and BioPharma team, you will have the opportunity to drive innovation and implement new ideas, continuously enhancing our emerging technology products and analytics to align with the evolving needs of the BioPharma landscape.

You will join an interdisciplinary team working with an unprecedented set of clinical DNA whole genome and exome sequence data and multiple epigenetic data types produced by novel R&D pipelines at Guardant Health. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA sequencing data, including cell free DNA-based transcript expression and methylation data integrated with epigenetic data sets. You will work together with our collaborators in industry, hospitals and academia on high-impact translational research and publish on your findings. You will have access to the unprecedented compendium of data collected at Guardant Health and you will be able to (and should be excited to!) leverage this data for tumor biology and technological insights.

Essential Duties and Responsibilities:

• Work with large, complex data sets.
• Tend to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data.
• Develop or apply statistical methods and procedures to evaluate and validate Guardant Health technologies.
• Systematically leverages external innovation ideas and expertise to address technology gaps and advance the Guardant Health's business.
• Provide analytical support on individual samples and research activities.
• Deliver analytical support for clinical operations in compliance with CLIA and CAP regulatory standards.
• Analyze genomic data from clinical patients and external annotation sources to improve the accuracy and quality of reporting.
• Develop scripts for research and development activities, and leverage cutting edge AI methods to continuously improve efficiency.
• Communicate research results through presentations and project reports as well as scientific publications.

• Ph.D. in Bioinformatics, Computational Biology, Statistics, Genomics or related fields.
• 5- 8 years experience in industry/academia post-graduation
• Established scientific expertise, demonstrated through peer-reviewed publications and/or contributions to successful product development in the biotech industry.
• In-depth knowledge of modern genomic tools and pipelines for processing and analyzing primary data, including somatic and structural variant detection.
• Extensive experience in next-generation sequencing (NGS) data analysis, including DNA, RNA, or epigenetic analysis.
• Proficiency in scripting languages (e.g., Python, R) and Linux shell environment, with a strong foundation in data analysis and interpretation.
• Strong written and verbal communication skills, with a proven ability to effectively convey complex scientific concepts and present clearly and effectively to stakeholders across organizations.
• Ability to thrive in a fast-paced startup environment, delivering high-quality results under tight timelines.
• Strong analytical and organizational skills, with the ability to synthesize complex concepts, drive projects forward, and maintain attention to detail.
• Collaborative team player, adept at working cross-functionally and across institutions to achieve shared goals.
• Bonus: Experience in developing novel or custom algorithms for NGS data interpretation.
• Bonus: Direct experience working with epigenomic data.

Work Environment:

• Employee may be required to lift routine office supplies and use office equipment.
• Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment.
• Ability to sit for extended periods of time.

Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The US base salary range for this full-time position is $133,540 to $183,560. The range does not include benefits, and if applicable, bonus, commission, or equity. The range displayed reflects the minimum and maximum target for new hire salaries across all US locations for the posted role with the exception of any locations specifically referenced below (if any).

For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $157,100 to $215,950. The range does not include benefits, and if applicable, bonus, commission, or equity.

Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above.

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.

Please visit our career page at: http://www.guardanthealth.com/jobs/

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.