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maria vougioukalakiMV
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maria vougioukalaki

@mariavougioukalaki

Molecular biologist at SyNoesis Therapeutics, studying molecular biology and protein interactions across ageing, DNA repair, and cancer.

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At SyNoesis Therapeutics, I work as a Scientific Advisor. My research background spans molecular biology, biochemistry, and protein and nucleic acid research in ageing, DNA damage repair, and cancer biology.

At Neotis Bio, I founded and led a project developing therapeutics for age-related degenerative disease, applying molecular glues to augment autophagic pathways. I took the project from concept to funded incubator selection.

At Erasmus MC, I studied how DNA damage contributes to ageing and cancer using fluorescent-reporter stem cells and organoids from repair-deficient mouse models. I developed organoid and 3D-culture assays and integrated imaging results with genome sequencing and mutational data.

Earlier, at the Institute of Molecular Biology & Biotechnology, I investigated inflammatory signaling and cell-adhesion pathways in cancer, and contributed to biochemical and structural research on translocase proteins. My work has appeared in peer-reviewed journals including Aging Cell and Genome Research.

Experience

Work history, roles, and key accomplishments

ST
Current

Scientific Advisor

SyNoesis Therapeutics

Aug 2024 - Present (2 years 2 months)

Serving as a scientific advisor, providing expert guidance on molecular biology and therapeutic development.

NB

Project Lead

Neotis Bio

Jan 2021 - Dec 2023 (2 years 11 months)

Founded and led a start-up developing therapeutics for age-related degenerative disease, applying molecular glues to augment autophagic pathways. Took the project from concept to funded incubator selection and owned project planning, team-building, strategic partnerships, and pitch development end to end.

IB

Post-graduate Scientist

Institute of Molecular Biology & Biotechnology

Oct 2007 - Jul 2013 (5 years 9 months)

Investigated crosstalk between TNF-related inflammatory signaling and cell-adhesion pathways in cancer cell growth and progression. Led project planning, experimental design, execution, and data interpretation across hypothesis-driven studies.

IB

Post-graduate & Undergraduate Scientist

Institute of Molecular Biology & Biotechnology

Sep 2003 - Sep 2006 (3 years)

Performed biochemical and structural characterization of Tim12 mitochondrial translocase and E. coli SecA translocase mutants using purified protein and lipid systems. Contributed to a publication in Nature Structural & Molecular Biology.

Education

Degrees, certifications, and relevant coursework

Erasmus MC logoEM

Erasmus MC

Ph.D., Molecular Genetics

Ph.D. in Molecular Genetics from Erasmus MC, Rotterdam, as a Marie Curie ITN pre-doctoral fellow.

University of Crete logoUC

University of Crete

M.Sc., Molecular Biology & Biomedicine

M.Sc. in Molecular Biology & Biomedicine from the University of Crete.

University of Crete logoUC

University of Crete

B.Sc., Biology

B.Sc. in Biology from the University of Crete.

Tech stack

Software and tools used professionally

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