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Eleni Geromichalou

@elenigeromichalou

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Translational pharmacologist with expertise in oncology drug discovery.

Greece

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What I'm looking for

I seek a collaborative environment where I can contribute to innovative drug discovery projects and advance my career in translational pharmacology.

I am a translational pharmacologist with over 5 years of experience in oncology-focused drug discovery, pharmacokinetics, and bioanalytical method development. My journey has been marked by a proven track record in designing and executing preclinical studies, where I integrate in vitro and in vivo pharmacology with advanced in silico drug design techniques.

Currently, as a Postdoctoral Research Scientist at Weill Cornell Medicine, I lead multiple preclinical studies that involve complex PK/PD modeling and biodistribution analyses. My expertise extends to developing innovative bioanalytical assays and utilizing cutting-edge technologies such as single-cell RNA sequencing and multicolor flow cytometry to gain mechanistic insights into drug efficacy and safety. I am passionate about leveraging my skills in computational drug design to accelerate the discovery of novel therapeutics.

Experience

Work history, roles, and key accomplishments

Current

Postdoctoral Research Scientist

Current

Weill Cornell Medicine

Jan 2022 - Present (3 years 7 months)

Designed and led over 10+ preclinical ADME, PK/PD, and biodistribution studies in rodent models, integrating bioanalytical assays, multicolor flow cytometry, and immunohistochemistry for compound profiling and mechanistic insight. Performed plasma and tissue drug quantification via ELISA and LC-MS/MS, correlating exposure with pharmacodynamic markers.

PD Modeling In Vivo Pharmacology

Research and Development Project Leader

Medicon Hellas S.A.

Jan 2020 - Present (5 years 7 months)

Designed, developed, and optimized immunoassays (ELISA, magnetic bead-based) for diagnostic and therapeutic applications, including protocols for targeted binding, separation, and high-sensitivity detection of large analytes. Developed and validated IVD reagents for use in clinical chemistry, immunochemistry, and hematology, ensuring analytical performance across automated platforms.

IVD Reagent Development Clinical Chemistry Hematology SOPs

Formulation Chemist

Private Pharmacy

Jan 2019 - Present (6 years 7 months)

Developed and optimized formulations for cosmetics, nutraceuticals, and OTC products, focusing on improving bioavailability, stability, and efficacy. Led lab-to-production scale-up of various dosage forms (emulsions, suspensions, liquids, capsules), ensuring formulation consistency and regulatory compliance.

Cosmetics Nutraceuticals OTC Bioavailability Scaling Regulatory Compliance Emulsions Suspension

Computer-Aided Drug Design Visitor Scientist

National Hellenic Research Foundation

Jan 2018 - Present (7 years 7 months)

Designed and optimized small-molecule drug candidates targeting key molecular pathways using molecular docking, QSAR modeling, and molecular dynamics simulations. Conducted high-throughput virtual screening and interaction analysis on large compound libraries to prioritize hits based on predicted binding affinities, pharmacophoric features, and ADMET properties.

Molecular Docking QSAR Modeling Molecular Dynamics PyMOL ADMET Drug Design

Education

Degrees, certifications, and relevant coursework

National and Kapodistrian University of Athens – Medical School

Doctor of Philosophy, Pharmacology

2016 - 2019

Investigated dual inhibition of oncogenic signaling pathways using novel steroid-based drug candidates. Applied computational drug design (Molecular Docking, Molecular Dynamics) for binding optimization and stability. Performed in vitro assays (ELISA, Flow Cytometry, Western Blot) to validate pharmacological activity and pathway inhibition. Designed and synthesized small molecules as part of early