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Andreas Wilm

@andreaswilm

Computational biology executive at ImmunoScape developing AI/ML models to predict T-cell target specificity from multi-omics data.

Singapore

Message

At ImmunoScape, I work on discovering and developing TCRs for the treatment of solid cancers. My team analyzes large multi-omics, single-cell datasets and develops AI/ML models to predict T-cell target specificity.

At the Genome Institute of Singapore, my team developed and operated scalable genome analytics workflows for next-generation sequencing data, including the National Precision Medicine pilot. We worked across an in-house HPC cluster, the National Supercomputing Centre, AWS, and other cloud providers.

Earlier, as a Research Associate at the Genome Institute of Singapore, I developed computational methods and workflows for next-generation sequencing analysis, particularly for RNA viruses such as Dengue and for metagenomics. I also worked with Illumina, PacBio, and Oxford Nanopore data.

At University College Dublin, I developed biological sequence analysis tools, including work on ClustalW2 and Clustal Omega, which have received more than 20,000 citations. At Microsoft, I helped customers across APAC adopt cloud solutions and designed architectures and pilots for machine learning, high-performance computing, and big data workloads.

Experience

Work history, roles, and key accomplishments

Current

Vice President, Computational Biology

Current

ImmunoScape

Mar 2025 - Present (1 year 6 months)

At ImmunoScape we discover and develop TCRs for the treatment of solid cancers. My team is responsible for the analysis of large multi-omics, single-cell data and development of AI/ML models to predict target specificity of T-cells.

Data Science Team Management Executive Management Computational Biology Machine Learning

Senior Director, Computational Biology

ImmunoScape

Jan 2024 - Mar 2025 (1 year 2 months)

Worked as Senior Director, Computational Biology at ImmunoScape.

Director of Computational Biology

ImmunoScape

Feb 2021 - Apr 2024 (3 years 2 months)

Worked as Director of Computational Biology at ImmunoScape.

Senior Cloud Solution Architect

Microsoft

Feb 2019 - Feb 2021 (2 years)

As a trusted technical advisor I empowered customers across the Asia Pacific region, especially those in higher education and research institutes successfully adopt Microsoft's cloud solutions and helped them with their digital transformation. My responsibilities included strategizing with key stakeholders and senior management as well as conducting workshops and training for knowledge transfer, d

Team Lead

Genome Institute of Singapore

Dec 2015 - Feb 2019 (3 years 2 months)

My team developed and operated scalable genome analytics workflows for the production analysis of all in-house next-generation sequencing data, including the National Precision Medicine pilot. We worked on heterogeneous compute systems, i.e. our in-house HPC cluster, the National Supercomputing Centre and increasingly on Amazon Web Services (AWS) and other cloud computing providers. We offered ISO

Research Associate

Genome Institute of Singapore

Nov 2010 - Dec 2015 (5 years 1 month)

During my time as Research Associate at the Genome Institute of Singapore I worked in the Computational & Systems Biology group of Niranjan Nagarajan. I developed and applied computational methods and workflows for the analysis of next-generation sequencing data, in particular for RNA virus (focus on Dengue), but also metagenomics samples. Apart from Illumina data, we further worked on the analysi

Postdoctoral Research Fellow

University College Dublin

Oct 2006 - Nov 2010 (4 years 1 month)

At Des Higgins' group at UCD I developed tools for biological sequence analysis. A major focus was on the Clustal series of alignment programs, including the widely used ClustalW2 and Clustal Omega (>20,000 citations). In addition I worked in collaboration with Cedric Notredame's group at the CRG Barcelona on programs for RNA structure alignment (e.g. R-Coffee).

IT Freelancer

Andreas Wilm

Jan 2005 - Jan 2006 (1 year)

As a side job during my final PhD years I worked as an IT freelancer, mainly as a PHP/MySQL programmer for Capsid GmbH, working on the back end for their job market platform jobvector.de

Education

Degrees, certifications, and relevant coursework

University of Düsseldorf

PhD, Biology

My PhD was sponsored by the prestigious German Academic Scholarship Foundation. The thesis was purely Bioinformatics focused and I graduated with highest honors (summa cum laude)