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Choon Kiat Sim User

@choonkiatsimuser

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Strategic computational biologist with expertise in AI-driven diagnostics.

Singapore

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What I'm looking for

I seek a role that fosters innovation and collaboration in biotechnology research.

I am a strategic computational biologist with a PhD in Genetics from Stanford and 19 years of experience in translational research. My specialization lies in AI-driven diagnostic solutions for infectious and autoimmune diseases, as well as synthetic biotechnology. I am passionate about leading research initiatives that enhance Singapore's defence capabilities through emerging technologies.

At Oasis Bio Pte Ltd, I spearhead AI-driven antibody discovery projects, utilizing advanced techniques like RFdiffusion and Alphafold3. My work focuses on developing diagnostic solutions for infectious diseases, optimizing protein expression, and enhancing analytical frameworks through R-based data pipelines. My previous roles at NUS and A*STAR have further honed my skills in microbiome analysis and stakeholder collaboration, resulting in numerous publications and invited talks that align with Singapore's health strategies.

With certifications in Project Management Essentials and Lean Six Sigma, I have successfully mentored students and led cross-functional teams. My analytical skills, combined with my commitment to technological innovation, position me to contribute effectively to DSO's mission and drive research excellence in the Defence Technology Community.

Experience

Work history, roles, and key accomplishments

Current

Scientist

Current

Oasis Bio Pte Ltd

Jan 2025 - Present (6 months)

Led AI-driven antibody discovery projects using RFdiffusion and Alphafold3, developing diagnostic solutions for infectious and autoimmune diseases, advancing synthetic biotechnology for biothreat detection. Optimized protein expression and purification (FPLC) for antibody/antigen targets, supporting defence-relevant assays.

Antibody Discovery RFDiffusion Protein Expression Diagnostics

Senior Research Fellow

National University of Singapore

Jan 2023 - Present (2 years 6 months)

Directed microbiome analysis for clinical cohorts, developing R-based pipelines with automated DNA extraction systems to inform health strategies for cancer immunotherapy. Collaborated with health agencies (NUHS), aligning research with Singapore’s precision medicine priorities.

Microbiome Analysis Precision Medicine Mentoring

Research Fellow

A*STAR

Jan 2020 - Present (5 years 6 months)

Led microbiome analysis for >500 clinical samples from GUSTO/S-PRESTO cohorts, informing respiratory health strategies. Engaged national research networks, delivering invited talks to align with Singapore’s health agenda.

Microbiome Analysis Statistical Modeling Metabolomics Public Speaking

Visiting Fellow

National Human Genome Research Institute, NIH

Jan 2016 - Present (9 years 6 months)

Developed a mouse model for antibiotic-resistant bacteria, with engineered gut microbial systems, publishing 3 papers. Served as liaison to NIH Child Care Board, coordinating stakeholder inputs for health initiatives.

Gut Microbial Systems Biothreat Diagnostics

Research Fellow

A*STAR

Jan 2012 - Present (13 years 6 months)

Mentored 3 undergraduate theses, guiding research on metabolic dysregulation and publishing 7 papers. Developed protocols for cell culture and proteomics, streamlining operations for research programs.

Mentoring Cell Culture Proteomics Research Collaboration

Lab Officer

Institute of Bioengineering and Nanotechnology

Jan 2006 - Present (19 years 6 months)

Mentored 3 engineering undergraduates, leading research tasks in a biomedical setting. Contributed to projects within the microfluidics laboratory.

Mentoring Research Tasks Biomedical Research Microfluidics

Education

Degrees, certifications, and relevant coursework

Stanford School of Medicine

PhD, Genetics

2007 - 2012

Activities and societies: Dissertation: Epigenetic Regulation of Olfactory Receptor Gene Expression; Stanford Ignite Program: Powering Innovation and Entrepreneurship

Completed a PhD in Genetics, with a dissertation focused on the epigenetic regulation of olfactory receptor gene expression. Participated in the Stanford Ignite Program, gaining insights into innovation and entrepreneurship.