Alexa Michel
@alexamichel
Senior Research Associate advancing gene-therapy bioanalytical assays for preclinical development.
United StatesWhat I'm looking for
I’m a Senior Research Associate with experience supporting gene therapy for preclinical development through bioanalytical assay execution, cross-functional collaboration, and scientific data analysis. At Vertex Pharmaceuticals, I lead analysis on preclinical studies (>1,000 samples), managing execution, data analysis, and delivery to stakeholders.
I specialize in qPCR, dPCR, LC-MS/HPLC, and pharmacokinetic workflows—conducting vector genome and transgene expression analysis, supporting IND-enabling method development (specificity, stability), and authoring bioanalytical reports for regulatory submissions (FDA IND support). I maintain rigorous electronic documentation (Benchling, LIMS), troubleshoot assay performance, and coordinate timelines and deliverables across multiple preclinical studies.
Experience
Work history, roles, and key accomplishments
Led bioanalytical analysis for preclinical gene therapy studies, managing execution and data delivery for 1,000+ samples. Developed and validated qPCR/branched DNA and LC-MS/HPLC methods, authored bioanalytical reports for FDA IND support, and maintained study traceability in Benchling and LIMS.
Performed DNA/RNA isolation and ddPCR analysis on liquid biopsy samples, designing mutation-specific assays to quantify mutation abundance. Coordinated shipments and sample tracking for WES/RNA-seq/NGS across institutions and supported publication outputs in the Corcoran Lab.
Processed human blood samples for clinical research, performing PBMC isolation and plasma preparation with strict sterile technique. Conducted cell counting and basic cell culture support while maintaining sample integrity for downstream analysis in the Immune Assessment Lab.
Education
Degrees, certifications, and relevant coursework
University of Connecticut
Bachelor of Science in Biology, Biology (Physiology and Neurobiology)
2016 - 2020
Activities and societies: Co-author on peer-reviewed publications: Cancer Discovery (2021), Clinical Cancer Research (2022), Cancer (2022), Nature Medicine (2023).
Bachelor of Science in Biology (major: Physiology and Neurobiology) completed in May 2020.
Availability
Location
United StatesAuthorized to work in
Job categories
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