Associate Principal Scientist, Imaging

Job Description

The Translational Imaging team at our Company's Research Laboratories in West Point, PA is seeking a talented Associate Principal Scientist to support the discovery and qualification of novel positron emission tomography (PET) tracers with their expertise in the application of radioligand binding assays. This Associate Principal Scientist will work in a collaborative research environment to support drug discovery programs across multiple therapeutic areas, with a focus on neuroscience and oncology.

Responsibilities:

• Design, optimize and perform in vitro radioligand binding assays, including autoradiography and tissue homogenate binding assays, to assess the binding characteristics of radioligands to support PET tracer discovery and development

• Analyze, interpret results and draw conclusions from experiments, and suggest, design, and pursue relevant experiments

• Generate reliable and reproducible data in a timely manner

• Present results and next steps at group meetings and project meetings

• Access and understand relevant scientific literature and apply theoretical framework to solving problems within scientific discipline in a timely manner.

• Work effectively with other scientists as part of a collaborative, multidisciplinary team

Qualifications:

Education:

• Master's (with 8+ years) or Ph.D. in biology, pharmacology, radiopharmaceutical sciences or related field and relevant work experience in the area of radiopharmaceutical discovery

Required Experience and Skills:

• Design, optimization, and implementation of radioligand binding experiments in tissue homogenate

• Design, optimization, and implementation of autoradiography experiments on tissue slices

• Sectioning of frozen tissue for autoradiography experiments

• Ability to independently design, execute and interpret in vitro radioligand binding experiments

• Analysis and interpretation of data from in vitro binding experiments using graphical nonlinear curve fitting software methods

• Theoretical knowledge of ligand-receptor binding interactions and their application to drug discovery

• Proven track record of generating publication quality data and contributing to manuscript or patent preparation.

• Highly developed oral and written communication skills and keen ability to engage internal and external team members in collaborative research

• Self-motivated and resourceful with good interpersonal skills

• Ability to independently manage workflow to see projects through from start to completion

• Strong interpersonal, verbal and written communication skills

• Willingness and ability to work with radioactive materials including ³H, 18F, and/or 89Zr.

• Strong record keeping skills

• Demonstrates a high level of attention to detail

Preferred Experience and Skills:

• Experience with molecular biology assays such as Western blot, ELISA, etc.

• Immunohistochemistry and/or immunofluorescence staining experience

#EligibleforERP

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Employee Status:

Regular

Relocation: