Looking for a job

Yadira PG

@yadirapg

Computational genomicist at Harvard Medical School building analyses of tumor sequencing to study clonal mixing, mutation selection, and cancer evolution.

United States

Message

At Harvard Medical School, I study clonal mixing across breast, colorectal, pancreatic, and other cancers using multi-region whole-exome sequencing. I analyze purity, ploidy, copy number, and cancer cell fractions to support clonal deconvolution.

I also study selection in breast tissue by calling somatic mutations from duplex sequencing and estimating selection with dN/dS. For this work, I prepare NGS libraries and test NanoSeq and TWIST protocol variants.

At Yale School of Public Health, I estimated neutral mutation rates and cancer effect sizes across tumor types, separating how often a variant arises from how strongly it is selected. I also built a workflow to phase poly-G repeat variants and detect clonal expansions or distinguish independent mutation events.

My PhD research at Indiana University focused on germline mutation rates and parental sex bias using pedigree whole-genome sequencing. I’ve also analyzed RNA-seq and small RNA-seq data, contributed to CAGEE, and co-authored peer-reviewed work across evolutionary and cancer genomics.

Experience

Work history, roles, and key accomplishments

Current

Postdoctoral Researcher in Cancer Evolution

Current

Harvard Medical School

Feb 2026 - Present (8 months)

Studies intratumoral heterogeneity and clonal mixing in multiple cancers using multi-region whole-exome sequencing, and estimates selection in tissues from duplex sequencing data. Also prepares NGS libraries and builds workflows for lineage analysis.

WGS WES Duplex Sequencing Copy Number Variation Analysis Clonal Deconvolution PyClone VI PhyClone DN DS Library Preparation Python R BASH Git Linux HPC Slurm Jupyter Conda

Postdoctoral Researcher in Biostatistics

Yale School of Public Health

Sep 2025 - Dec 2025 (3 months)

Estimated neutral mutation rates and cancer effect sizes of somatic variants across tumor types, separating variant occurrence from selection strength.

Cancer Genomics Mutation Rate Estimation Selection Analysis Cancer Effect Size Statistical Genetics

PhD in Genome, Cell, and Developmental Biology

Indiana University

Sep 2020 - Dec 2025 (5 years 3 months)

Estimated germline mutation rates and parental sex bias from pedigree whole-genome sequencing in opossum, grizzly bear, and aye-aye, and timed de novo and somatic mutations in rhesus macaque offspring and placenta.

WGS Variant Calling Somatic Mutation Detection Mutation Rate Estimation CAGEE Python R BASH Git Linux HPC Slurm Jupyter Conda

MSc in Biotechnology

West Virginia State University

Jan 2018 - Dec 2020 (2 years 11 months)

Analyzed RNA-seq and small RNA-seq data for expression profiling and miRNA identification, and characterized an F-box gene regulating arsenic tolerance in Arabidopsis.

RNAseq SmallRNA Sequencing Transcriptomics Molecular Cloning Agrobacterium Mediated Transformation Arabidopsis Capsicum

BSc in Biochemical Engineering

Autonomous University of Coahuila

Aug 2012 - May 2017 (4 years 9 months)

Graduated with High Distinction. Completed undergraduate studies in biochemical engineering.

Education

Degrees, certifications, and relevant coursework

Harvard Medical School

Postdoctoral Researcher, Cancer Evolution

2026 -

Postdoctoral research in cancer evolution, studying intratumoral heterogeneity and selection in tissues using multi-region whole-exome and duplex sequencing data.

Indiana University

Doctor of Philosophy, Genome, Cell, and Developmental Biology

2020 - 2025

PhD in Genome, Cell, and Developmental Biology with a minor in Bioinformatics. Research focused on germline mutation rates and somatic mutation timing using pedigree whole-genome sequencing.

Yale School of Public Health

Postdoctoral Researcher, Biostatistics

2025 - 2025

Postdoctoral research in biostatistics, estimating neutral mutation rates and cancer effect sizes of somatic variants across tumor types.

West Virginia State University

Master of Science, Biotechnology

2018 - 2020

MSc in Biotechnology with research in transcriptomics and functional genetics, including analysis of RNA-seq and small RNA-seq data and characterization of an arsenic tolerance gene in Arabidopsis.