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Weiyi Ni

@weiyini

Head of RWE analytics driving evidence generation for market access, pricing, and reimbursement through real-world data and HEOR.

United States

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What I'm looking for

I’m looking to lead integrated RWE/HEOR programs that generate decision-ready evidence for market access and reimbursement, with strong scientific rigor, compliant SOPs, and cross-functional partnership—backed by modern data governance and scalable analytics.

I lead integrated evidence generation strategy to close clinical and global market access–related evidence gaps in partnership with medical affairs, commercial, regulatory, and clinical development teams. I’m especially focused on observational and epidemiologic study design that produces decision-ready real-world evidence.

In my most recent roles as Head of RWE Analytics and Director, Global Value – HEOR at Jazz Pharmaceuticals, I oversaw pivotal RWE studies to support launches, including work for Xywav and Ziihera in the U.S. market. I also directed HCRU studies using Optum Market Clarity to inform post-approval strategy and payer engagement in biliary tract cancer.

I build rigorous evidence programs end-to-end—planning, data curation, and analysis—using EMR, claims, registry, genomic, and survey data to generate evidence on disease burden, treatment patterns, effectiveness, and safety. I’ve also developed enterprise-wide reimbursement strategies and strengthened real-world data governance through implementation of data quality standards, metadata governance, data lineage, and scalable infrastructure for reproducibility, traceability, and regulatory readiness.

I enjoy communicating complex findings clearly to clinical, regulatory, and policy stakeholders, supported by a strong publication record and scientific presentations. I’ve led and mentored high-performing RWE teams, established global RWE operating frameworks and SOPs, and championed advanced data visualization to improve how RWE results—like comorbidity and HCRU profiles—translate into actionable payer-facing value propositions.

Experience

Work history, roles, and key accomplishments

Head of RWE Analytics

Jazz Pharmaceuticals

Dec 2022 - Apr 2026 (3 years 4 months)

Led RWE analytics and integrated evidence generation efforts to support global market access, pricing, and reimbursement. Managed cross-functional evidence programs, real-world data governance, and SOP/framework development to ensure scientific rigor and regulatory readiness.

Real World Evidence (RWE)Integrated Evidence Generation Health Economics and Outcomes Research (HEOR)Data Governance Data Lineage Reimbursement Strategy Data Visualization Cross functional Leadership Optum Market Clarity SAS Stata SPSS R Panalgo Instant Health Data

Director, Global Value – HEOR

Jazz Pharmaceuticals

Oct 2020 - Nov 2022 (2 years 1 month)

Directed global HEOR and value evidence programs by planning and executing real-world studies to close evidence gaps for market access and reimbursement. Translated analytical findings into stakeholder-facing value propositions for medical, regulatory, and commercial teams.

HEOR Real World Evidence (RWE)Healthcare Data Economic Modeling literature review Value Proposition Development Payer Engagement Reimbursement Strategy Data Visualization Cross Functional Collaboration SAS Stata SPSS R Panalgo Instant Health Data

Senior Health Economist

Medtronic

Jul 2018 - Oct 2020 (2 years 3 months)

Conducted cost-effectiveness and administrative claims analyses to support market access and reimbursement strategy. Produced payer-facing value briefs and synthesized evidence across literature, clinical trials, and claims to inform value-based healthcare strategy.

Cost Effectiveness Analysis Value Briefs Cross Functional Collaboration SAS Stata SPSS R

Associate Director, Health Outcomes Res.

Millennium Health

Sep 2017 - Jan 2018 (4 months)

Led health outcomes research activities using EMR data and developed economic models to evaluate clinical and economic impact. Supported payer-perspective budget impact analyses for diagnostic and policy-related strategies.

Health Outcomes Research EMR Based Retrospective Study Budget Impact Analyses Health Economics and Outcomes Research (HEOR)Cross Functional Collaboration SAS Stata SPSS R

Senior Manager, Health Outcomes Research

Millennium Health

Sep 2016 - Sep 2017 (1 year)

Conducted health outcomes research using EMR data to assess healthcare utilization and costs associated with clinical outcomes. Built budget impact models to evaluate the economic value of diagnostics in inpatient settings and supported managed markets analyses for payer impact.

Health Outcomes Research EMR Based Retrospective Study Budget Impact Analyses Healthcare Utilization Management Claims Analysis SAS Stata SPSS R

Consultant

EconoMedRx

May 2014 - Sep 2016 (2 years 4 months)

Performed cost-effectiveness analyses and developed analytic methods to support reimbursement and access decisions. Supported claims-based investigations including lines-of-therapy algorithms and identification of off-label medication use.

Cost Effectiveness Analysis Diagnostic Test Economic Evaluation Empirical Payment Modeling Off Label Utilization Identification Drug Indication SAS Stata SPSS R

Education

Degrees, certifications, and relevant coursework

University of Southern California

Doctor of Philosophy, Pharmaceutical Economics and Policy

2012 - 2017

Ph.D. in Pharmaceutical Economics and Policy from the University of Southern California (2012–2017).

University of Florida

Doctor of Philosophy, Medical Sciences (Genetics)

2007 - 2012

Ph.D. in Medical Sciences – Genetics with a minor in Statistics from the University of Florida (2007–2012). Dissertation: “Investigation of the Status of Recombinant Adeno-Associated Viral Vectors in Non-Human Primate Peripheral Blood Mononuclear Cells Transduced Collaterally in vivo.”

Fudan University

Bachelor of Science, Biological Sciences

2003 - 2007

B.S. in Biological Sciences from Fudan University (2003–2007).

University of Southern California

Master of Arts, Economics

M.A. in Economics from the University of Southern California. Dissertation: “Impact of Pharmacy-Based Transitional Care on Healthcare Utilization and Costs.”