Open to opportunities

Melissa DeSanto

@melissadesanto

Message

I build regulatory-ready clinical analyses for brain, cardiovascular, and chronic disease research.

United States

Message

What I'm looking for

I'm looking to lead rigorous, reproducible clinical and real-world evidence analyses that improve brain and heart health, support regulatory decisions, and connect prevention-focused evidence to patient outcomes.

At Meditrial, I design pre-specified analysis plans and reproducible pipelines for clinical trials, observational studies, and medical technology evaluations across neuropsychiatric, cardiovascular, and other therapeutic areas.

Previously, at the United States Department of Defense and Defense Health Agency, I analyzed EHR and administrative data for safety surveillance, comparative effectiveness, operational health, and brain/behavioral-health outcomes. I've delivered Cox, Kaplan-Meier, mixed-effects, MMRM, GEE, IPTW, and propensity-score analyses while maintaining source-to-analysis-to-TLF traceability.

My work connects rigorous modeling to prevention-oriented brain and heart health, using SAS, R, Python, SQL, CDISC concepts, and regulatory-aligned statistical methods to support clinical and regulatory decisions.

Experience

Work history, roles, and key accomplishments

Current

Lead Bio-Statistician

Current

Meditrial

Jun 2026 - Present (2 months)

Designs pre-specified statistical analysis plans for clinical trials and observational studies, develops predictive models using restricted cubic splines, and validates models against regulatory requirements. Collaborates with cross-functional teams to deliver reproducible analyses supporting evidence-based decision making.