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sina kiani

@sinakiani

Bioinformatics graduate researcher at Fraunhofer ITEM who developed and integrated a mechanistic kidney model into a PBK framework.

Germany
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At Fraunhofer ITEM, I developed a virtual human kidney model in R to represent renal transport processes, then integrated the mechanistic model into the institute’s PBK framework. I validated it through a case study in the ADME4NGRA project and presented the results to an international project consortium.

My bioinformatics work includes building BioRNAlytics, a web-based platform that helps researchers run differential gene expression analyses without programming. It processes RNA-seq count matrices, identifies significantly expressed genes, and presents biological data with interactive visualizations.

At Ceyoniq Technology GmbH, I performed automated and manual quality assurance for server applications and documented software defects. My studies at Universität Bielefeld also included RNA-sequencing analysis of human cardiac stem cells and a CWL workflow for Oxford Nanopore sequencing data.

Experience

Work history, roles, and key accomplishments

Fraunhofer ITEM logoFI

Werkstudent In-Silico Toxikologie

Fraunhofer ITEM

Oct 2025 - Sep 2026 (11 months)

Developed a mechanistic kidney model and integrated it into the institute's physiologically based kinetic (PBK) model. Validated the integrated model using a case study in the ADME4NGRA project and presented results to an international consortium.

Fraunhofer ITEM logoFI

Masterand

Fraunhofer ITEM

Apr 2025 - Sep 2025 (5 months)

Developed a virtual human kidney in R to model renal transport processes mechanistically. Implemented an ODE-based model with mass balances and active transport using Michaelis-Menten kinetics.

CG

Werkstudent Forschung & Entwicklung

Ceyoniq Technology GmbH

Nov 2022 - Sep 2025 (2 years 10 months)

Performed automated and manual quality assurance of server applications in an agile software development environment. Identified, analyzed, and documented technical software issues to ensure robust enterprise applications.

Education

Degrees, certifications, and relevant coursework

Universität Bielefeld logoUB

Universität Bielefeld

Master of Science, Bioinformatik und Genomforschung

2024 -

Grade: 1.0

Activities and societies: Development of CWL workflow for Oxford Nanopore sequencing data analysis; bioinformatics analysis of human promoter sequences.

Master of Science in Bioinformatik und Genomforschung with focus on algorithms in genome research, image processing, deep learning, and biological network analysis. Master's thesis on ODE-based mechanistic kidney model integration into a PBK framework, grade 1.0.

Universität Bielefeld logoUB

Universität Bielefeld

Bachelor of Science, Bioinformatik und Genomforschung

2019 - 2024

Grade: 1.0

Activities and societies: Bioinformatics project on differential gene expression in NF-kB role in human cardiac stem cells; software group project developing a full-stack application for managing measurement data on railway routes using Java and Vue.js.

Bachelor of Science in Bioinformatik und Genomforschung with focus on sequence analysis, genome research, data visualization, software development, and databases. Bachelor's thesis on expression analysis of serum-mediated effects on human cardiac stem cells, grade 1.0.

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