Open to opportunities

ashi bar sapir

@ashibarsapir

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Oncology scientist and medical director with 15+ years of experience.

Israel

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What I'm looking for

I am looking for opportunities that allow me to lead innovative projects in oncology, collaborate with multidisciplinary teams, and contribute to advancements in precision medicine.

I am an oncology scientist and medical director with over 15 years of experience in biologic drug discovery and AI-powered clinical solutions. My journey has been marked by a passion for leveraging technology to transform precision oncology and improve patient outcomes. I have successfully led antibody and ADC programs, and directed AI-driven platforms that enhance clinical trial access for cancer patients.

Throughout my career, I have designed and implemented AI-powered clinical trial-matching tools, collaborated with major pharmaceutical companies, and built partnerships that drive innovation in cancer care delivery. My PhD work focused on immune profiling and personalized medicine, which has equipped me with a robust understanding of tumor immunology and therapeutic antibody discovery.

Experience

Work history, roles, and key accomplishments

Current

Principal Scientist– Immuno-Oncology & ADC Development

Current

Biolojic Design

Jan 2024 - Present (1 year 5 months)

Leads research and development for novel ADC programs targeting solid tumors. Designs and executes functional cell-based assays to evaluate antibody efficacy, optimizing antibody candidates via yeast display and high-throughput screening.

Cell Based Assays Yeast Display Bioinformatics

Medical Director

Leal Health

Jan 2021 - Present (4 years 5 months)

Directed the Lung and Mesothelioma Cancer Medical Team, developing AI-powered clinical decision tools to match patients with clinical trials. Validated medical components of the digital platform, ensuring high accuracy, regulatory compliance, and clinical precision.

AI Powered Clinical Decision Tools Clinical Trial Matching Oncology Regulatory Compliance Cross Functional Collaboration Data Analysis

Senior Scientist (PhD), Protein Engineering & Antibody Technologies

Merck KGaA

Jan 2016 - Present (9 years 5 months)

Completed PhD thesis work within Merck KGaA’s R&D division, investigating tumor immunology using yeast display antibody libraries derived from tumor-infiltrating B cells. Developed novel screening strategies for therapeutic antibody discovery and led various screening techniques including yeast display and FACS sorting.

Tumor Immunology Yeast Display Antibody Libraries FACS Sorting Bio Panning Antibody Discovery Biochemical Strategies

Project Leader – ADC Development

Merck KGaA

Jan 2014 - Present (11 years 5 months)

Led antibody-drug conjugate development, overseeing the process from initial target screening through to validation. Managed project timelines and resources to ensure successful program progression.

Screening Validation Drug Discovery

Senior Technician – Oncology & Immuno-Oncology R&D

Merck KGaA

Jan 2009 - Present (16 years 5 months)

Participated in end-to-end therapeutic antibody development processes, contributing to various stages of research and development. Supported experimental design and execution within oncology and immuno-oncology R&D initiatives.

Oncology research and development

Process Controller – Manufacturing Upstream

Serono S.A.

Jan 2000 - Present (25 years 5 months)

Monitored and controlled Interferon beta (Rebif®) production in bioreactors, ensuring adherence to manufacturing protocols and quality standards. Managed upstream processing operations to optimize yield and purity.

Controls Processes Manufacturing Interferon Beta Production Quality Control

Education

Degrees, certifications, and relevant coursework

Technical University Darmstadt

PhD, Biochemistry

Completed PhD thesis work focusing on the evaluation of yeast display Fab libraries derived from tumor-infiltrating B cells. This research supported tumor immunology and personalized medicine initiatives.

Hebrew University of Jerusalem

M.Sc.Agr, Biochemistry & Food Sciences

Grade: Cum Laude

Conducted research for Master's thesis on the immunochemical and molecular detection of Atenolol in food and environmental samples. Graduated with Cum Laude honors.

Hebrew University of Jerusalem

B.Sc, Animal Science & Agricultural Economics

Studied foundational principles in Animal Science and Agricultural Economics. Gained knowledge in areas relevant to agricultural practices and economic aspects of the field.