Alexandra Moser
@alexandramoser
I develop iPSC-based therapies and disease models for Alzheimer's disease and aging.
United StatesWhat I'm looking for
At Cedars-Sinai, I lead research on how genetic ancestry, sex, APOE4, and epigenetic regulation shape Alzheimer's disease risk, microglial function, and vascular aging.
I've led work showing that human iPSC-derived mononuclear phagocytes improve cognition and neural health across mouse models of aging and Alzheimer's disease, published in Advanced Science. My research combines iPSC-derived immune and brain-cell models, 3D brain chips, CRISPR editing, transcriptomics, plasma proteomics, and in vivo disease models to identify therapeutic mechanisms and biomarkers.
I'm an independent PI, mentor, educator, IRB and stem-cell oversight committee member, and Associate Editor for the Journal of Alzheimer's Disease. I enjoy building collaborative programs that translate stem-cell biology into therapies for neurodegenerative disease.
Experience
Work history, roles, and key accomplishments
Investigates mechanisms underlying racial disparities in Alzheimer's disease risk, including genetic ancestry and epigenetic regulation. Develops iPSC-derived 3D brain chips to study sex differences and APOE4 effects on vascular aging.
Designed and led a research program demonstrating that human iPSC-derived mononuclear phagocytes improve cognition and neural health in mouse models of aging and Alzheimer's disease. Elucidated mechanisms using co-culture systems, transcriptomics, and plasma proteomics.
Demonstrated how APOE4 genotype and sex interact to drive transcriptional and functional microglial phenotypes across mouse and human iPSC-derived models. Generated and characterized patient-derived iPSC lines and applied CRISPR genome editing.
Investigated gene-by-environment interactions in Alzheimer's disease, focusing on obesity and metabolic dysfunction interacting with APOE genotype. Identified TLR4 signaling as a key pathway mediating adverse neural effects of high-fat diet.
Education
Degrees, certifications, and relevant coursework
University of Southern California
Doctor of Philosophy, Neuroscience
2012 - 2018
PhD in Neuroscience with thesis on the role of inflammation in mediating effects of obesity on Alzheimer's disease.
Furman University
Bachelor of Science, Psychology
Grade: cum laude
BS in Psychology, cum laude.
Availability
Location
United StatesAuthorized to work in
Job categories
Skills
Interested in hiring Alexandra?
You can contact Alexandra and 90k+ other talented remote workers on Himalayas.
Message AlexandraGet matched with your dream remote job
Sign up now and join over 250,000+ remote workers who receive personalized job alerts, curated job matches, and more for free!
