At Lowy Cancer Research Centre, I analyze shallow whole-genome sequencing and complementary molecular data from the international OTTA high-grade serous ovarian cancer cohort. I’m developing chromosomal-instability classifications from sWGS data that are used to inform PARP inhibitor stratification.
At ProCan, Children’s Medical Research Institute, I analyzed DIA mass-spectrometry proteomics for triple-negative breast cancer and small round blue cell cancers. I also arranged a collaboration to develop an RUV variant for DIA data.
Through Gentrepid, I developed methods to identify candidate disease genes for inherited phenotypes and made them available through a public web service. The work extended to applying the methods to GWAS data and translating findings toward therapeutics.
I teach computational statistics and data science at the University of Sydney, most recently in the Master of Data Science program. Across my research, I use reproducible workflows to take multi-omics data from preprocessing and quality control through statistical analysis and biological interpretation.
