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EpistemixEP

Infrastructure Architect

Epistemix is a simulation platform that uses synthetic populations to help organizations forecast outcomes and manage risks by modeling human behavior.

Epistemix

Employee count: 11-50

United States only

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Our Infrastructure Architectserves as the critical technical expert responsible for all post-sales deployment and integration of the Epistemix platform into client infrastructure. This is a highly technical, hands-on role.

You will be the vital link between our product's architecture and our clients' varied technical landscapes. This role requires the ability to be both a hands-on architect and navigating complex client IT, security, and application environments (AWS, GCP, private cloud, or on-prem) to successfully deploy our product and ensure immediate value realization.

About Epistemix

The most consequential decisions in public health, life sciences, insurance, and enterprise strategy share a common problem: they involve human behavior, network effects, and downstream effects that cannot be safely tested before action is taken. Traditional analytical techniques built on historical data were not built for this. Epistemix was.

We build simulation and data-driven modeling tools that let leaders visualize how strategies will unfold across populations and systems before they commit resources. By clarifying which variables drive outcomes, where leverage exists, and how they interact, we help organizations move from uncertainty to conviction. Getting these decisions right means faster interventions, better-allocated resources, and measurable improvements in human and economic outcomes. We exist to make that possible.

Our platform gives organizations access to realistic, high-resolution population data and the modeling infrastructure to run scenario planning at scale. Together, these capabilities let decision-makers stress-test strategies in a controlled environment before deploying them in the real world across healthcare, consumer industries, insurance, and government. We are approaching our Series B and actively building the team that will define what comes next.

Responsibilities

  • Design and execute the technical strategy for integrating the Epistemix platform into client environments.

  • Leverage Terraform, Kubernetes and Docker across client environments, ensuring security and repeatability with a primary focus on AWS and data connections like Snowflake and Databricks.

  • Interface with client IT organization to understand infrastructure environment and provide architectural guidance during implementation.

  • Ensure all client-side integration and deployment methods are designed to meet rigorous standards, including SOC 2 and ISO 27001, HIPAA.

  • Work with client IT organizations to set deployments in complex settings, including public cloud (AWS/GCP), private cloud, and traditional on-premises/dedicated application environments.

  • Develop and use custom automation tooling (Python is a must) to streamline deployment processes, integrating with client-side identity and access management (e.g., OAuth2/OIDC).

Qualifications

  • 8+ years of industry experience, 3+ years of architectural implementation experience

  • Hands on and expert level experience in:

    • Python, Fast API and/or Django

    • Terraform. Additional knowledge of Kubernetes, and Docker highly preferred.

    • AWS infrastructure. General architectural mastery of another major cloud provider (GCP) is highly valued.

  • Bachelors Degree in Computer Science or a relevant technical discipline such as Mathematics, Statistics, Epidemiology, or Public Health

  • Demonstrated experience managing or contributing to organizational compliance programs, specifically the development and implementation of policies and procedures related to HIPAA (HITECH Act) privacy/security rules and achieving SOC 2 attestation

  • Experience with data warehouse integrations with Snowflake, Databricks or other data warehouse platforms.

  • Experience managing and supporting deployments in environments beyond public cloud (e.g., on-premise, private cloud, or dedicated client application environments).

Nice to Have Experience

  • Familiarity with the architectural demands of distributed computing libraries (Ray, Modin, Pandas) is highly valued.

  • Familiarity with JavaScript/TypeScript, Node.js, and React.

  • Familiarity with leveraging generative AI tools in engineering workflows (e.g., Claude Code, Devin, Coderabbit).

Why Join Epistemix?

By joining Epistemix, you will become part of a collaborative and rapidly growing team that values curiosity and creativity. We are fully remote, with team members in the United States and Europe. Benefits include:

  • Equity & Incentives – Participation in our stock option program.

  • Flexible Time Off – Autonomy to manage your schedule and work-life balance.

  • Health, Welfare and 401(k) Programs – Eligibility for benefits (for U.S. employees).

  • Meaningful Impact – Apply your creative talents to revolutionize data-driven decision-making and make a real-world difference.

This is a remote position open to applicants located in the United States. Candidates must possess the legal right to work in their intended work location, as we are currently unable to sponsor or transfer employment visas for any country, including the United States.

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United States +/- 0 hours

About Epistemix

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The story of Epistemix begins long before its official founding, rooted in decades of academic research at the University of Pittsburgh. In the early 2000s, Dr. Donald Burke and Dr. John Grefenstette, two leading figures in epidemiology and public health, began developing a powerful modeling system known as FRED (Framework for Reconstructing Epidemiological Dynamics). Their goal was to create a tool that could simulate the spread of infectious diseases with unprecedented accuracy, using synthetic populations that mirrored the real world down to the individual level. For years, this technology remained a specialized academic asset, used primarily to understand and predict public health crises.

In 2018, recognizing the potential of this technology to solve complex problems beyond just epidemiology, Burke and Grefenstette teamed up with John Cordier to spin the technology out into a commercial entity. Thus, Epistemix was born. The trio sought to democratize access to these advanced simulations, enabling organizations across various sectors—from government agencies to event organizers—to forecast outcomes and manage risks with confidence. By simulating how people behave and interact in a statistically accurate virtual world, Epistemix empowers leaders to test strategies and make data-driven decisions in an increasingly complex and interconnected society.

Employee benefits

Learn about the employee benefits and perks provided at Epistemix.

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Stock Options

Participation in the company stock option program.

401(k) Program

Retirement savings plan for eligible U.S. employees.

Flexible Time Off

Autonomy to manage your schedule and work-life balance.

Health & Welfare

Comprehensive health and welfare benefits for eligible employees.

View Epistemix's employee benefits
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