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Yashraj KulkarniYK
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Yashraj Kulkarni

@yashrajkulkarni

Computational biochemist at the University of Copenhagen, where I developed a novel peptide design approach for GPCR discovery.

Denmark
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At the University of Copenhagen, I drove early-stage peptide drug discovery projects targeting GPCRs, contributing to ideation, proposal development, and execution. I led the development of a novel peptide design approach, using data-driven pivots and iterative hypothesis testing to navigate scientific uncertainty.

I also took ownership of an existing research project outside my initial focus area, built domain knowledge, coordinated with collaborators, and drove the project to completion and publication. I worked with multidisciplinary teams to integrate computational design and experimental pharmacology and contribute to strategies for translational potential and IP relevance.

At MIT, I investigated enzyme structural dynamics using molecular simulations. At Uppsala University, I led research projects on enzyme catalysis and protein dynamics, built models to rationalize mutational effects on enzyme function, and collaborated with structural biologists on cancer-associated protein mutations.

My work spans protein and peptide discovery, GPCR biology, and computational design, with 12 scientific publications on structure-based drug design, enzyme catalysis, and protein dynamics. Earlier, at ZS Associates, I used big data analytics to enhance strategic decision-making for pharmaceutical clients.

Experience

Work history, roles, and key accomplishments

Education

Degrees, certifications, and relevant coursework

Uppsala University logoUU

Uppsala University

Ph.D., Biochemistry

2015 - 2020

Ph.D. in Biochemistry with a focus on computational modeling of biomolecular systems.

Uppsala University logoUU

Uppsala University

M.Sc., Applied Biotechnology

2013 - 2015

M.Sc. in Applied Biotechnology, with a thesis on using dynamic correlation networks to predict mutability hotspots.

RE

RV College of Engineering

B.E., Biotechnology

2008 - 2012

B.E. in Biotechnology, with a project on transesterification of fatty acids in wastewater sludge to produce biodiesel.

Tech stack

Software and tools used professionally

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