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Ebube Onwasigwe

@ebubeonwasigwe

Clinical Research Physician specializing in oncology and immunology, driving drug development through clinical trial leadership.

United States

Message

What I'm looking for

I seek senior clinical development roles in oncology or immunology to lead late-stage trials, guide regulatory strategy, mentor teams, and translate biomarkers into safer, effective therapies in collaborative, science-driven environments.

I am a Clinical Research Physician with ten years of preclinical and clinical research experience focused on oncology and immunology. I have provided medical oversight for pivotal phase 3 trials, contributed to a successful BLA submission for a therapy to treat recurrent or metastatic cervical cancer, and led programs across oncology, neuro-oncology and vaccines while maintaining compliance with FDA, ICH, GCP, and TPD standards.

I excel at medical monitoring, pharmacovigilance, protocol design, biomarker identification, and cross-functional stakeholder management, and I have prepared manuscripts, regulatory packages and scientific presentations. I am motivated to lead clinical development teams that translate translational science into safer, more effective therapies and innovative interventions for chronic and rare diseases.

Experience

Work history, roles, and key accomplishments

Current

Clinical Lead

Current

Pfizer

Feb 2023 - Present (2 years 6 months)

Provided medical oversight on pivotal Phase 3 immuno-oncology trials including tisotumab vedotin, leading to successful trial completion and BLA submission; managed cross-functional stakeholders, CROs, and site personnel to ensure safety and efficacy assessment.

Oncology RECIST 1.1 BLA Submission Pharmacovigilance CRO

Associate Medical Director

AstraZeneca

Apr 2021 - Mar 2022 (11 months)

Supported design and execution of late-stage (Ph2b and pivotal Phase III) vaccine trials for Nirsevimab, performing medical monitoring, safety oversight, and protocol/amendment development to advance regulatory objectives.

CTMS Pharmacovigilance

Education

Degrees, certifications, and relevant coursework

Alabama A&M University

Doctor of Philosophy, Biochemistry

2014 - 2017

Activities and societies: Conducted in vivo and in vitro oncology studies, biochemical assays (ELISA, HPLC), animal handling under IACUC, manuscript and abstract preparation, and supervised undergraduate students.

Completed a Doctor of Philosophy in Biochemistry with doctoral research on the antioxidant and anticarcinogenic effects of allspice and completion of a doctoral dissertation.

South Carolina State University

Master of Science, Clinical Nutrition

2012 - 2014

Activities and societies: Managed clinical interventions, patient screening and recruitment, dietary recalls, blood biomarker analysis (glucose, insulin, HbA1c, lipid profile), protocol development, and SAS-based data analysis.

Completed a Master's program focused on clinical nutrition with emphasis on dietary interventions and research in elderly type II diabetics.

University of Debrecen, Medical and Health Science Center

Doctor of Medicine, Medicine

2005 - 2011

Activities and societies: Completed clinical rotations and clerkships, participated in diagnostic procedures including fluorescence angiography, and gained hands-on inpatient and surgical experience.

Earned a Doctor of Medicine degree with clinical rotations in psychiatry, neurology, ophthalmology and a thesis on fluorescence angiography for diagnosing intraocular tumors.