Senior Manager, People Operations

Role Overview & Key Functions:

SUMMARY:

The Senior Manager, People Operations is responsible for leading and optimizing core employee lifecycle processes across the organization. This role serves as a trusted partner to leaders and employees, ensuring operational excellence, compliance, and a seamless employee experience throughout all stages of employment. The Senior Manager will oversee HR operational programs, lead process improvement initiatives, and partner cross-functionally to support the company’s people strategy

At Karyopharm, our HR team is a strategic partner to the business while creating a thoughtful, high-quality employee experience grounded in collaboration, responsiveness, and continuous improvement.

RESPONSIBILITIES:

• Leads and oversees the employee onboarding and offboarding experience in partnership with key stakeholders.
• Partners with HR leadership to develop and execute strategic People Operations initiatives aligned with business objectives.
• Oversees employee recognition and engagement programs to support a positive and inclusive company culture.
• Manages and enhances onboarding programs, including onboarding agendas and the new hire buddy program.
• Ensures compliance with employment eligibility verification requirements and oversees all I-9 documentation processes.
• Provides guidance to employees and managers regarding HR policies, procedures, and best practices.
• Collaborates cross-functionally with IT, Payroll, Facilities, Administration, Quality, Legal, and other teams to ensure operational effectiveness.
• Oversees HRIS data integrity, reporting, employee records management, onboarding and offboarding documentation, and audit readiness.
• Drives process improvement initiatives and implements scalable operational efficiencies across HR workflows and procedures.
• Manages vendor relationships related to background checks, immigration, employment verifications, HR systems, and other HR operational services.
• Partners with HR Centers of Excellence during key annual processes, including performance reviews, compensation planning, succession planning, and engagement surveys.
• Oversees legal contract coordination, budget tracking, and purchase order processing for the HR function.
• Assists and manages immigration processes for new and existing employee cases in partnership with external counsel and internal stakeholders.
• Partners with Compensation and Finance teams to support equity administration and organizational planning processes.
• Collaborates with HR leadership to execute strategic Human Resources initiatives and change management activities.
• Leads the review and maintenance process to ensure all job descriptions are accurate, compliant, and aligned with organizational structure.
• Facilitates new hire orientation sessions and supports leadership development and employee training initiatives.
• Oversees offboarding activities, including separation documentation, benefits communications, exit interviews, and risk mitigation activities.
• Partners with Payroll to ensure accurate and timely payroll-related documentation and processing.
• Supports Inclusion & Wellness initiatives and programs through strategic planning, communication, and execution.
• Leads HR compliance activities related to GxP training records, audit readiness, SOP management, and documentation retention requirements.
• Partners with Talent Acquisition and hiring managers to support workforce planning, hiring operations, and onboarding activities.
• Leverages AI-driven tools, HR analytics, and workforce data insights to enhance operational efficiency, support strategic decision-making, improve employee experience, and drive continuous process improvement across the HR function. Develops and analyzes HR metrics and reporting related to turnover, headcount, engagement, and operational performance.
• Leads the adoption and governance of AI-enabled HR technologies and people analytics to optimize workforce planning, operational effectiveness, and employee engagement strategies.
• Acts as a trusted advisor to managers and employees on employee relations matters, organizational changes, and HR operational practices.
• Ensures compliance with federal, state, and local employment laws, including leave administration, accommodations, and policy administration.

Candidate Profile & Requirements:

REQUIREMENTS:

• Bachelor’s degree; Master’s degree or HR certification preferred.
• Minimum of 8 years of Human Resources experience, including at least 5 years in HR Operations or People Operations leadership roles.
• Experience leveraging AI tools and technologies to improve HR operations, reporting, employee experience, and process automation required.
• Experience within the biotechnology, pharmaceutical, healthcare, or other regulated industry strongly preferred
• Strong interpersonal, conflict resolution, verbal, written, and presentation communication skills
• Experience managing vendor relationships, budgets, and cross-functional projects.
• Excellent organizational skills with the ability to manage multiple priorities and projects simultaneously.

• Strong attention to detail and commitment to data accuracy, confidentiality, and compliance.

• Process improvement mindset with the ability to identify and implement operational efficiencies.
• Comprehensive knowledge of employment laws, HR compliance requirements, and HR best practices.
• Experience with HRIS systems and advanced proficiency in Microsoft Office applications preferred.

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $XXX K - $XXX K USD.

Our Value Proposition:

This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.

Our lead therapy, XPOVIO® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.

As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.

Learn more at Karyopharm Therapeutics.