Thomas Bobinski
@thomasbobinski
Experienced medicinal chemist with a focus on drug discovery.
What I'm looking for
I am a dedicated medicinal chemist with extensive experience in drug discovery and development, particularly in optimizing synthetic methodologies and leading cross-functional teams. My work has significantly contributed to the advancement of FDA-approved therapies, including Krazati™ (adagrasib), where I led strategic development initiatives that enhanced synthesis efficiency by 500%.
Throughout my career, I have successfully managed complex projects from inception to clinical candidate nomination, utilizing advanced computational chemistry techniques and structure-based drug design. My leadership at Mirati Therapeutics and Cervello Therapeutics has resulted in accelerated target deployment and improved potency for various inhibitors, showcasing my ability to drive innovation and achieve measurable results in the pharmaceutical industry.
Experience
Work history, roles, and key accomplishments
Director, Medicinal Chemistry
Cervello Therapeutics
Nov 2019 - May 2025 (5 years 6 months)
Optimized synthesis with a team of nine FTEs, accelerating lead compound potency screening and reducing cycle time by 30% using applied organic chemistry techniques. Led cross-functional meetings biweekly to integrate SBDD approaches, achieving 5- to 10-fold acceleration in target deployment.
Director, Medicinal Chemistry
Cervello Therapeutics
Nov 2019 - Feb 2020 (3 months)
Streamlined PLK1 covalent inhibitor pipeline via computational chemistry techniques, reducing proprietary design timelines 10-fold. Enhanced HTRF assay sensitivity for PLK1 inhibitor evaluation, resulting in a 40% improvement in assay precision.
Principle Scientist
Mirati Therapeutics
Feb 2017 - Nov 2019 (2 years 9 months)
Optimized experimental techniques promoting MRTX1719's transition to an IND clinical candidate with targeted efficiency in PRMT5 inhibition. Leveraged surface plasmon resonance (SPR) screening to identify fragments with weak binding affinity for PRMT5 targets.
Senior Scientist
Mirati Therapeutics
Oct 2016 - Feb 2017 (4 months)
Directed the development of synthetic methods, resulting in FDA approval of adagrasib (Krazati), demonstrating a robust impact on target-specific therapies with quantified progression metrics. Implemented advanced synthetic techniques, achieving a 10-fold increase in diversification efficiency for the 5, 6, 7, 8-Tetrahydropyrido 3, 4-d pyrimidine core.
Scientist I
Ignyta
Nov 2015 - Jun 2016 (7 months)
Structural databases were used to enhance pharmacophores with Schrödinger software, increasing the lead identification efficiency by 30% (KRAS). Optimized synthesis workflow to efficiently produce advanced intermediates and final compounds within a streamlined ten-step process, boosting compound assessment speed by 15% (KRAS).
Research Associate
Starks Associate
May 2003 - Aug 2007 (4 years 3 months)
Boosted API project outcomes, achieving a 15% cost saving by pioneering new chemistry techniques and collaborating with national research partners and leveraging NMR spectroscopy. Applied organic chemical expertise to deliver high-purity compounds that meet research standards.
Education
Degrees, certifications, and relevant coursework
Purdue University
Doctor of Philosophy (Ph.D.), Chemistry, Organic Division
Grade: 3.57
Completed a Ph.D. in Chemistry with a focus on Organic Chemistry. The program involved extensive research and advanced coursework in the field.
The State University of New York at Buffalo
B.S. / M.S., Medicinal Chemistry
Grade: 3.67
Obtained both Bachelor of Science and Master of Science degrees in Medicinal Chemistry. The curriculum provided a strong foundation in drug discovery and development.
Tech stack
Software and tools used professionally
Availability
Location
Authorized to work in
Job categories
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