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David Streett

@davidstreett

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Staff software engineer and team lead building high-performance, data-intensive systems.

United States

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What I'm looking for

I seek technical leadership roles where I can lead teams to build scalable, cost-efficient cloud-native systems, optimize performance, and deliver compliant software in high-throughput environments.

I am a staff software engineer and team lead with extensive experience designing and optimizing high-throughput, data-intensive systems for adTech and regulated bioinformatics environments. I have led teams to replace legacy platforms, improved performance and cost-efficiency on AWS, and built cloud-native exchanges and real-time auction platforms handling hundreds of billions of requests.

I co-founded a biotech startup delivering doctor-facing and regulatory software across Europe, built NGS and diagnostic pipelines, and contributed open-source tooling with broad adoption. I combine hands-on systems optimization (C++, Java, Python), cloud migrations, and cross-functional leadership to deliver reliable, performant, and compliant software solutions.

Experience

Work history, roles, and key accomplishments

Current

Staff Software Engineer

Current

Sovrn

May 2024 - Present (1 year 11 months)

Lead a team of 6 developers to replace multiple legacy systems, improved a real-time adtech auction platform to run on 100% spot instances and reduced infrastructure costs while adding fail-safes and cloud-native exchange functionality.

Java Kubernetes ArgoCD Kafka Redis AWS Performance Optimization Microservices

CTO & Co-Founder

Karilian

May 2021 - Mar 2024 (2 years 10 months)

Co-founded and led development of doctor-facing biotechnology software for NGS sequencing and regulatory deployments across hospitals in Spain, Germany, and Switzerland, built APIs and clinician tools that supported clinical workflows.

Python Django React GraphQL AWS JavaScript NoSQL Bioinformatics

Senior Software Engineer

SpotX

Jun 2020 - May 2021 (11 months)

Ported and optimized a codebase from PHP to C++17/20, reducing API call latency to under 250ms and profiling/optimizing systems to handle billions of daily requests, improving reliability and revenue.

PHP SQL CI CD Valgrind Profiling Performance Optimization Linux

Senior Software Engineer III

ArcherDx

Mar 2018 - Jun 2020 (2 years 3 months)

Maintained and improved core RUO and FDA-regulated diagnostic software, developed diagnostic releases for international markets, and optimized NGS data transformation pipelines to reduce runtimes and memory usage.

C Python R Docker NGSTooling BASH Linux CI CD

Bioinformatics Analyst

Brigham and Women's Hospital

Jul 2017 - Mar 2018 (8 months)

Updated clinical and research NGS pipelines for the oncology team, implemented ML methods to detect contamination, and transitioned the team to agile practices while productionizing ML algorithms.

Python Flask GCP Unix NGSTooling Git

Education

Degrees, certifications, and relevant coursework

University of Idaho

Master of Science, Bioinformatics and Computational Biology

2015 - 2017

Master of Science in Bioinformatics and Computational Biology emphasizing bioinformatics, NGS data processing, and software development for biomedical applications.