Lead Statistician HEOR

Work Schedule

Environmental Conditions

Job Description

The Lead Statistician works with multi-disciplinary research teams to provide methodological expertise, leadership and strategic support at all stages of projects from planning to completion. This individual provides guidance to junior and middle level staff or works independently on projects requiring advanced statistical analysis, interpretation and dissemination of findings.

Essential Duties and Responsibilities (other duties may be assigned):

Statistical Analysis Plan (SAP) Development

• Draft SAPs for projects that require use of advanced statistical methodologies
• Advise junior and middle level staff on methodology and approach on projects requiring use of standard statistical methodologies
• Review and approve SAPs projects that require use of standard statistical methodologies

Implementation & Interpretation of Analyses

• Project Lead (including execution of analyses) on project requiring the use of advanced statistical methodologies
• Provide guidance and advice as needed for junior and mid-level staff on projects requiring use of standard statistical methodologies

Proposal Writing and Report Preparation

• Lead proposal development in familiar project-types or take a supportive role for more complex projects
• Determine technical approach, review proposal drafts and take responsibility of stats components
• Get involved in client discussions
• Obtain significant levels of repeat business from clients
• May lead technical response to requests for proposals, generates repeat work and amendments
• May identify opportunities for new work
• May advise and peer-review budget

Communication with internal/external Clients

• Lead meetings and discussions with clients
• Act as an escalation point for client concerns related to the project
• Communicate effectively and proactively with project teams
• Ability to work with and delegate to junior and mid-level staff, responsible for deliverable quality and integrity
• Review and support presentations by more junior staff

Consulting Expectations

• Provide on-the-spot problem-solving and consulting in discussions of results
• Provide methodological expertise within and outside the team

Methodological Development

• Contribute to the conceptualization and development of novel/bespoke solutions to meet client project needs
• Independently investigate the properties, applicability and advantages/disadvantages of both:
• Methodologies developed by Evidera as bespoke solutions to client projects
• Newly published methodologies, and seeks senior input when needed
• May lead the development of parts of tools/macros that improve efficiency of project execution, seeking senior input when needed
• Provide technical training on the tools developed within HEMA

Scientific Presence

• Develop and implement the best scientific practices/guidelines, product development/new methods, or deliverable standards
• Support external thought leadership through publications and workshops
• Look for opportunities to disseminate knowledge

Financialand managerial

• Responsible for achieving utilization and proposal and sales target
• Can supervise and mentor junior and middle level staff, involvement in hiring and development of staff, conducting performance reviews.

In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Education, Professional Skills & Experience:

• PhD in Biostatistics/Statistics or related field with 4+ years of experience, MSc in Biostatistics/Statistics or related field with 6+ years of experience, or BSc in Biostatistics/Statistics or related field with 8+ years of experience
• Strong basis in fundamental statistical concepts and methods, and expertise with techniques such as regression analysis (continuous, binary, count data), longitudinal data analysis (mixed effects linear regression), parametric and semi-parametric survival analysis, meta-analysis, indirect treatment comparisons, issues related to missing data, etc.
• Practical experience in standard statistical applications in health economics such as:
  o Standard parametric and semi-parametric survival analyses
  o Flexible parametric models (spline, piecewise)
  o ITC methods (Bucher, network meta-analyses [NMA], matching-adjusted indirect comparisons [MAICs], simulated treatment comparisons)
  o Country-specific utility analyses to inform CEMs
• Familiarity with complex methods, including:
  o Projecting incomplete survival data using Bayesian parametric survival models with informative priors
  o Adjustment for treatment switching (rank preserving structural failure time, inverse probability of censoring weighting, two-stage estimation)

  o Mixture cure models

  o multi-state models

  o Multilevel network meta-regression and fractional polynomial NMA
  o Surrogacy analyses

• Strong statistical programming skills with standard software, including R and/or STATA/SAS
• Ability to communicate analysis plans and results to clients or colleagues who may have limited background in statistics
• Scientific visibility in terms of authorship of peer-reviewed publications, podium presentations and posters at conferences
• Leading development and deployment of technology solutions for initiatives involving automation or AI-enablement in statistics and other areas in health economics and market access will be an asset

Thermo Fisher values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:

• Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
• Able to work upright and stationary for typical working hours.
• Ability to use and learn standard office equipment and technology with proficiency.
• Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.
• May require travel. (Recruiter will provide more details.)

Compensation and Benefits

This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

• A choice of national medical and dental plans, and a national vision plan, including health incentive programs

• Employee assistance and family support programs, including commuter benefits and tuition reimbursement

• At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy

• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan

• Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards