# Heena A Shah Heena A Shah is a remote worker on Himalayas, Assistant Manager – Bioinformatics at Microcrispr, based in India. Source: https://himalayas.app/@heenaashah ```text Bioinformatics Assistant Manager at Microcrispr developing CRISPR off-target pipelines and statistical frameworks for genomic analysis. ``` | Detail | Value | | --- | --- | | Availability | Looking for a job | | Location | India | | Authorized to work in | India | | Salary expectations | 16600k+ INR | | Job categories | Bioinformatics Scientist, Bioinformatics Analyst | | Skills | Bioinformatics, Off Target Analysis, Amplicon Sequencing, Hybrid Capture Target Enrichment, SITE Seq, WES, WGS, CtDNA, Single Cell Transcriptomics, Genomics, Clinical Genomics, Multi omics, Variant Analysis, Genomic Surveillance, Statistical Modeling | | LinkedIn | https://linkedin.com/in/Heena-Shah | ## About ```text At Microcrispr, I design bioinformatics pipelines for CRISPR off-target evaluation and quantify editing efficiency across target sites. I also direct Amplicon sequencing and Hybrid Capture processing and lead computational setup and onboarding for SITE-seq. At Breast Cancer Now, Institute of Cancer Research (ICR), I developed and deployed HPC pipelines for clinical genomics analysis. I analyzed somatic and germline variants across breast and head and neck cancer studies, and profiled biomarkers including TMB, MSI, CNVs, PAM50, and TNBC subtypes. I integrated multi-omics data, including Nanostring RNA, 10X Single-Cell transcriptomics, TCR-seq, and methylation datasets. I also applied survival modeling and machine learning to identify prognostic molecular patterns and actionable clinical biomarkers. Earlier, at the National Genomics Core, CDFD, I built automated WGS pipelines for COVID-19 genomic surveillance and GISAID submissions. My work has also included livestock genotyping and imputation at NDDB, cancer genome analysis at Binstech, and cytogenetic screening at Jaslok Hospital & Research Centre. ``` ## Experience ### Assistant Manager – Bioinformatics (current) Microcrispr. Jul 2026 - Present ```text Designed bioinformatics pipelines for off-target CRISPR evaluation and quantified editing efficiency across target sites. Led end-to-end processing of Amplicon sequencing and Hybrid Capture assays, and developed custom statistical modeling frameworks. ``` Skills: Off-Target-Analysis, Amplicon-Sequencing, Hybrid-Capture-Target-Enrichment, SITE-Seq, Statistical-Modeling, Data-Normalization, Workflow-Automation, Nextflow, Python, R, Linux, HPC ### Analytical Scientist Bioinformatics – Molecular Oncology Breast Cancer Now, Institute of Cancer Research (ICR). Feb 2023 - Jun 2025 ```text Developed and deployed scalable HPC pipelines for clinical genomics analysis, analyzing somatic and germline variants in WES, WGS, ctDNA, and FFPE tissue. Applied survival modeling and machine learning to discover prognostic molecular patterns and clinical biomarkers. ``` Skills: Nextflow, GATK-Best-Practices, Slurm, Python, R, WES, WGS, CtDNA, Liquid-Biopsy, TMB, MSI-Installers, Mutation-Signatures, CNV, PAM50, TNBC-Subtyping, Nanostring-RNA, 10X-Single-Cell, TCR-Seq, Methylation, Survival-Analysis, Machine-Learning ### Technical Associate (Computational) National Genomics Core, Center for DNA Fingerprinting and Di. Jun 2020 - Feb 2021 ```text Built automated WGS pipelines for COVID-19 genomic surveillance and high-throughput GISAID repository submissions. Analyzed RNA-Seq, ChIP-Seq, and WGS datasets for variant identification and downstream statistical interpretation. ``` Skills: WGS, Covid-19, GISAID, RNAseq, ChIP-Seq, Variant-Calling, HPC, Linux, Illumina, Oxford-Nanopore ### Trainee Bioinformatics – Animal Breeding National Dairy Development Board (NDDB). Jan 2019 - Apr 2020 ```text Extracted phenotypic and demographic livestock data using SQL and performed SNP chip genotyping with GenomeStudio. Conducted GWAS, genotype imputation, and population structure analysis. ``` Skills: SQL, SNP-Genotyping, Genome-Studio, PLINK, Beagle, Genome-Wide-Association-Studies-(GWAS), Imputation, Admixture, ChromoPainting, PCA, NGS, Hi-C, Salsa ### Intern Data Science Simple and Real Analytics. Nov 2017 - Mar 2018 ```text Applied machine learning algorithms and statistical modeling in Python and R for data classification and analytical projects. ``` Skills: Machine-Learning, Python, R, Statistical-Modeling, Data-Classification ### Bioinformatics Analyst Binstech. May 2016 - Jul 2017 ```text Conducted cancer genome data analysis utilizing pharmacogenomics bioinformatics software. ``` Skills: Cancer-Genomics, Pharmacogenomics, Bioinformatics ### PhD Research Fellow – Genetics and Assisted Reproduction Jaslok Hospital & Research Centre. May 2013 - Apr 2014 ```text Conducted FISH and karyotyping cytogenetic techniques for aneuploidy screening. ``` Skills: FISH, Karyotyping, Cytogenetics, Prenatal-Screening ### Lecturer (Biotechnology & Microbiology) S.S. & L.S. Patkar-Varde College. Jun 2010 - Dec 2013 ```text Taught biotechnology and microbiology courses to undergraduate students. ``` Skills: Teaching, Biotech, Microbiology ### Lecturer (Biotechnology) Viva College. Aug 2009 - Apr 2010 ```text Taught biotechnology courses to undergraduate students. ``` Skills: Teaching, Biotech ## Education ### Mumbai University M.Sc., Biotechnology. Grade: 66.00% ```text Completed M.Sc. in Biotechnology with 66.00% from Mumbai University in July 2009. ``` ### Mumbai University B.Sc., Biotechnology. Grade: 61.72% ```text Completed B.Sc. in Biotechnology with 61.72% from Mumbai University in June 2007. ``` ## Tech stack - Python - scikit-learn - Linux - Docker - SQL - Nextflow - Bash - Conda - Shiny - AWS To contact Heena A, message them from this profile with a Himalayas employer account: [Hire on Himalayas](https://himalayas.app/hire). ## People also viewed - [Aditya Naman Soni](https://himalayas.app/@ansoni10): Junior research fellow, Institute of Bioinformatics and Applied Biotechnology - [Subinoy Biswas](https://himalayas.app/@subinoybiswas): Bioinformatician, Freelance - [Mahima John](https://himalayas.app/@mahimajohn): Bioinformatics Research Intern, Biotechnika - [SUCHANDA DEY](https://himalayas.app/@suchandadey): Project Coordinator, AAS International Private Limited - [Parth Doshi](https://himalayas.app/@parthdoshi): Statistical Genetics Consultant, Freelance - [Dipti Gulumbe](https://himalayas.app/@diptigulumbe): Bioinformatics Scientist, Chromosome Labs Private Limited - [Neha Shaikh](https://himalayas.app/@nehashaikh2): Bioinformatician, Datar Cancer Genetics - [Siba User](https://himalayas.app/@sibauser): Project Associate – II, BRIC – Centre for DNA Fingerprinting and Diagnostics (CDFD) - [Ashwini User](https://himalayas.app/@ashwiniuser3): Clinicogenomics Analytics Manager, ConcertAI - [GANESH ASWAL](https://himalayas.app/@ganeshaswal): Officer – Quality Control, Naari Pharma Pvt. 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